cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2014-6-56-61cardiovascular-83Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEMКИШЕЧНАЯ МИКРОБИОТА — НОВЫЙ ИГРОК В ПАТОГЕНЕЗЕ АТЕРОСКЛЕРОЗАGUT ENTEROBIOTA — A NEW PLAYER IN ATHEROSCLEROSIS PATHOGENESISЕгшатянЛ. В.EgshatyanL. V.

к.м.н., м.н.с. отдела изучения старения и профилактики возраст-ассоциированных заболеваний

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lilit.egshatyan@yandex.ruТкачеваО. Н.TkachevaO. N.

д.м.н., профессор, первый заместитель директора по научной и лечебной работе

БойцовС. А.BoytsovS. A.

д.м.н., профессор, директор

ФГБУ “Государственный научно-исследовательский центр профилактической медицины” Министерства здравоохранения Российской Федерации, МоскваFSBI State Scientific-Research Centre for Preventive Medicine of the Ministry of Health of Russian Federation, Moscow2014201220141365661Copyright © Егшатян Л.В., Ткачева О.Н., Бойцов С.А., 20142014Егшатян Л.В., Ткачева О.Н., Бойцов С.А.Egshatyan L.V., Tkacheva O.N., Boytsov S.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/83

В статье представлен обзор современной литературы, обобщающий экспериментальные и клинические данные о роли кишечной микробиоты в развитии атеросклероза. Микрофлора кишечника является своеобразным маркером состояния макроорганизма, реагируя на возрастные, физиологические, диетические, климато-географические факторы изменением качественного и количественного составов. Показано, что L-карнитин и холин, получаемые с пищей, используются микрофлорой кишечника для синтеза три-метиламина, который быстро окисляется флавинмонооксигеназой в печени до триметиламин–N-оксида, вызывающего развитие атеросклероза и повышающего риск развития сердечно-сосудистых заболеваний. 

The article provides a review of contemporary literature, which generalizes experimental and clinical data on the role of gut microbiota in atherosclerosis development. Gut microflora can be named a marker of the macroorganism condition, reacting on age-related, physiological, dietic, climatogeoraphic factors with its changes of qualitative and quantitative compounds. It was shown that L-carnitine and choline being received with food, are utilized by microflora to synthetize trimethylamine, which then rapidly oxydized by flavinmonooxygenase of liver to trimethylamin-N-oxide, that causes atherosclerosis development and increases risk of cardiovscular diseases.

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The authors declare that there are no conflicts of interest present.