cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2018-6-95-109cardiovascular-832Research ArticleОБЗОРЫREVIEWSАмбулаторное мониторирование пульсовых волн: статус проблемы и перспективы. Позиция российских экспертовAmbulatory pulse wave monitoring: current and future. Opinion paper of Russian Expertshttps://orcid.org/0000-0002-8160-5612КотовскаяЮ. В.KotovskayaYu. V.

Котовская Юлия Викторовна — доктор медицинских наук, профессор, заместитель директора по научной работе.

Москва

Moscow

ryabova_ev@rgnkc.ruhttps://orcid.org/0000-0002-4829-0954РогозаА. Н.RogozaA. N.

Рогоза Анатолий Николаевич — доктор биологических наук, профессор, руководитель отдела новых методов исследования.

Москва

Moscow

anrogoza@gmail.comhttps://orcid.org/0000-0002-8160-5612ОрловаЯ. А.OrlovaYa. A.

Орлова Яна Артуровна — доктор медицинских наук, заведующая отделом возраст-ассоциированных заболеваний обособленного подразделения Медицинского научно-образовательного центра

YAOrlova@mc.msu.ruhttps://orcid.org/0000-0002-2381-0351ПосоховИ. Н.PosokhovI. N.

Посохов Игорь Николаевич — доктор медицинских наук.

Нижний Новгород

Nizhny Novgorod

igor@posohov.ruРоссийский геронтологический научно-клинический центр, ОСП, ФГБОУ ВО РНИМУ им. Н.И. Пирогова Минздрава РоссииRussian Gerontology Clinical Research Center of the Ministry of HealthФГБУ “Национальный медицинский исследовательский центр кардиологии” Минздрава РоссииScientific Medical Research Center of Cardiology of the Ministry of HealthФГБОУ ВО Московский государственный университет имени М. В. ЛомоносоваLomonosov Moscow State UniversityЛаборатория Гемодинамики, ОООLaboratoriya Gemodinamiki Ltd20182012201817695109Copyright © Котовская Ю.В., Рогоза А.Н., Орлова Я.А., Посохов И.Н., 20182018Котовская Ю.В., Рогоза А.Н., Орлова Я.А., Посохов И.Н.Kotovskaya Y.V., Rogoza A.N., Orlova Y.A., Posokhov I.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/832

Прогностическое значение биомаркеров состояния артериальной стенки, определяемых при анализе пульсовых волн (ПВ) в состоянии покоя, — скорости распространения ПВ, центрального артериального систолического и пульсового давления, аортального индекса аугментации, — хорошо документировано в различных популяциях. Эти данные позволили научным сообществам сформулировать соответствующие рекомендации по их использованию в клинической практике. Благодаря техническим достижениям все более доступны автоматические методы оценки упомянутых выше параметров в амбулаторных условиях в течение сут. На данный момент отсутствует достаточное количество результатов исследований для широкого клинического использования амбулаторного суточного мониторирования ПВ и его рутинного клинического применения. Однако, исходя из приемлемой погрешности и воспроизводимости данных, полученных этим методом, его интегрированности с суточным мониторированием артериального давления в плечевой артерии, этот подход представляется перспективным для оценки биомаркеров состояния сосудистой стенке уже на этапе диагностики артериальной гипертонии. Он может обеспечить дальнейшее усовершенствование раннего скрининга пациентов с высоким риском сердечно-сосудистых заболеваний. Необходимы проспективные долгосрочные исследования с оценкой исходов, чтобы показать прогностическое значение суточного мониторирования скорости распространения ПВ, центрального артериального давления и индекса аугментации, измеряемых приборами во всем диапазоне периферического артериального давления и ответить на открытые технические и клинические вопросы.

The predictive value of vascular biomarkers such as pulse wave velocity (PWV), central arterial pressure (CAP), and augmentation index (AIx), obtained through pulse wave analysis (PWA) in resting conditions, has been documented in a variety of patient groups and populations. There are appropriate recommendations on their clinical use in clinical practice guidelines of various scientific societies. Operator-independent methods are currently available for estimating vascular biomarkers also in ambulatory conditions. The acceptable accuracy and reproducibility of ambulatory PWA makes it be a promising tool for evaluating vascular biomarkers in daily-life conditions. This approach may provide an opportunity to further improve the early cardiovascular screening in subjects at risk. However, there is no sufficient evidence to support the routine clinical use of PWA in ambulatory conditions at the moment. In particular, long-term outcome studies are needed to show the predictive value of ambulatory PWV, CAP and AIx values.

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The authors declare that there are no conflicts of interest present.