cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2018-4-95-102cardiovascular-844Research ArticleОБЗОРЫREVIEWSСосудистая жесткость, кальцификация и остеопороз. Общие патогенетические звеньяVessel stiffness, calcification and osteoporosis. Common pathogenetic componentshttps://orcid.org/0000-0002-1763-0725СкрипниковаИ. А.SkripnikovaI. A.

Скрипникова Ирина Анатольевна — доктор медицинских наук, руководитель отдела профилактики остеопороза.

Москва, +7 (916) 672-40-23

Moscow

ISkripnikova@gnicpm.ruhttps://orcid.org/0000-0002-9752-6839АбироваЭ. С.AbirovaE. S.

Абирова Эсет Султановна — кандидат медицинских наук, старший научный сотрудник отдела профилактики остеопороза.

Moscow

eabirova@gnicpm.ruhttps://orcid.org/0000-0001-7426-7179АлихановаН. А.AlikhanovaN. A.

Алиханова Нурвият Арсланалиевна — кандидат медицинских наук, младший научный сотрудник отдела профилактики остеопороза.

Moscow

nuriyat1901@yandex.ruhttps://orcid.org/0000-0001-7036-4756КосматоваО. В.KosmatovaO. V.

Косматова Ольга Владимировна — кандидат медицинских наук, старший научный сотрудник отдела профилактики остеопороза.

Москва

Moscow

okosmatova@gnicpm.ruФГБУ “Национальный медицинский центр профилактической медицины” Минздрава РоссииРоссияNational Medical Research Centre of Prevention Medicine of the Ministry of HealthRussian Federation20182008201817495102Copyright © Скрипникова И.А., Абирова Э.С., Алиханова Н.А., Косматова О.В., 20182018Скрипникова И.А., Абирова Э.С., Алиханова Н.А., Косматова О.В.Skripnikova I.A., Abirova E.S., Alikhanova N.A., Kosmatova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/844

Атеросклероз и остеопороз до недавнего времени считали заболеваниями современного общества, а одновременное развитие их связывали с  простым накоплением этих заболеваний при удлинении продолжительности жизни. В настоящее время есть исследования, убедительно демонстрирующие, что этими заболеваниями страдали древние популяции, независимо от возраста и пола. Обнаружение этих заболеваний у людей в более молодом возрасте, живших во времена древнеегипетской цивилизации, свидетельствует в пользу общих генетических и поведенческих факторов риска и звеньев патогенеза, нежели простого их накопления с возрастом. В зарубежной литературе появляется все больше и больше публикаций об общих чертах этих заболеваний и сходстве в патогенетических механизмах. Высокий риск преждевременной смерти от осложнений атеросклероза и остеопороза способствует поиску индивидуальных и общих предикторов заболеваний с  целью их своевременной профилактики. Лечение проявлений атеросклероза и  остеопороза у  одного пациента требует использования множества препаратов, что вызывает полипрагмазию. В обзоре обсуждаются общие механизмы развития сосудистой ригидности, кальцификации и снижения костной массы. Глубокое понимание этих механизмов будет способствовать открытию новых мишеней, воздействуя на которые одним препаратом, можно будет снизить риски развития осложнений.

Atherosclerosis and osteoporosis until recently were regarded as the diseases of modern society, and their simultaneous development was explained just by the increased chances with longevity. Currently, there are studies showing evidence on these diseases in ancient populations, regardless the age and gender. The diseases found in younger age, with the early Egyptian civilization, witness on the common genetic and behavioral risk factors and pathogenetic components, than simple age-related chance. Scientific publications show more and more data on common properties of these diseases and pathogenetic mechanisms. High risk of premature death from atherosclerosis and osteoporosis complications facilitates the search for individual and general predictors of the disorders with the aim of on-time prevention. Treatment of atherosclerosis and osteoporosis presentation events in one patient demands for a range of medications that leads to polypragmasia. The review is focused on common mechanisms of vascular stiffness development, calcification and bone density decrease. Profound understanding might make it to open novel targets for one drug to both diseases, with decreased rate of complications.

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The authors declare that there are no conflicts of interest present.