cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2018-3-85-95cardiovascular-845Research ArticleОБЗОРЫREVIEWSНОВАЯ ФИКСИРОВАННАЯ КОМБИНАЦИЯ ИНГИБИТОРА АНГИОТЕНЗИН-ПРЕВРАЩАЮЩЕГО ФЕРМЕНТА ПЕРИНДОПРИЛА И ВЫСОКОСЕЛЕКТИВНОГО β-АДРЕНОБЛОКАТОРА БИСОПРОЛОЛА: ПЕРВАЯ СРЕДИ РАВНЫХNOVEL COMBINATION OF THE ANGIOTENSIN CONVERTING ENZYME INHIBITOR PERINDOPRIL AND HIGHLY SELECTIVE β-ADRENOBLOCKER BISOPROLOL: PRIME AMONG THE EQUALОстроумоваО. Д.OstroumovaO. D.

Доктор медицинских наук, профессор, профессор кафедры факультетской терапии и профболезней МГМСУ им. А. И. Евдокимова; профессор кафедры клинической фармакологии и пропедевтики внутренних болезней сеченовского университета

КочетковА. И.KochetkovA. I.

Кандидат медицинских наук, ассистент кафедры факультетской терапии и профболезней

СтародубоваА. В.StarodubovaA. V.

Доктор медицинских наук, заместитель директора по научной и лечебной работе ФИЦ питания, биотехнологии и безопасности пищи; профессор кафедры факультетской терапии лечебного факультета РНИМУ им. Н.И.Пирогова

ГусеваТ. В.GusevaТ. F.

Кандидат медицинских наук, доцент кафедры факультетской терапии и профболезней

ФГБОУ ВО Московский государственный медико-стоматологический университет им. А. И. Евдокимова Минздрава России4 ФГАОУ ВО Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России (Сеченовский Университет)A. I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health; I.M. Sechenov First Moscow State Medical University of the Ministry of HealthФГБОУ ВО Московский государственный медико-стоматологический университет им. А. И. Евдокимова Минздрава РоссииA. I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Health. MoscowФГБУН Федеральный исследовательский центр питания, биотехнологии и безопасности пищи; ФГБОУ ВО Российский национальный исследовательский медицинский университет имени Н. И. Пирогова Минздрава РоссииFederal Research Cneter of Food, Biotechnologies and Food Safety; N. I. Pirogov Russian National Research Medical University of the Ministry of Health2018200620181738595Copyright © Остроумова О.Д., Кочетков А.И., Стародубова А.В., Гусева Т.В., 20182018Остроумова О.Д., Кочетков А.И., Стародубова А.В., Гусева Т.В.Ostroumova O.D., Kochetkov A.I., Starodubova A.V., Guseva Т.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/845

В статье представлена обширная доказательная база антигипертензивной эффективности и безопасности периндоприла и бисопролола. Рассмотрены вопросы применения этих препаратов у пациентов с артериальной гипертонией, ишемической болезнью сердца и хронической сердечной недостаточностью согласно международным и отечественным клиническим рекомендациям. Особое внимание уделено влиянию периндоприла и бисопролола на прогноз — риск развития сердечно-сосудистых осложнений с точки зрения доказательной медицины. Приведены данные о новой уникальной фиксированной комбинации этих препаратов, рассмотрены ее преимущества и механизм комплементарного действия, представлены результаты рандомизированных, клинических исследований, указывающие на высокий потенциал такой схемы комбинированного лечения.

The article is focused on a broad evidence of antihypertension efficacy of perindopril and bisoprolol. The issues considered, of the drugs usage in patients with arterial hypertension, ischemic heart disease and chronic heart failure according to the international and local clinical guidelines. Special attention is paid for the influence of perindopril and bisoprolol on prognosis — the risk of cardiovascular complications from the evidence based medicine perspective. The data provided on a novel unique combination of these medications, and the benefits are accounted, as the mechanism of complimentary interaction; the results of randomized trials, clinical trials provided, that point on the high potential of this sort of combinational treatment.

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The authors declare that there are no conflicts of interest present.