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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2019-2-20-25</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-868</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОСТРЫЙ КОРОНАРНЫЙ СИНДРОМ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ACUTE CORONARY SYNDROME</subject></subj-group></article-categories><title-group><article-title>Эхо-кардиографические показатели при фибрилляции предсердий в сочетании с острым коронарным синдромом в реальной клинической практике по данным тотального регистра острого коронарного синдрома по Краснодарскому краю</article-title><trans-title-group xml:lang="en"><trans-title>Echo-cardiographic parameters for atrial fibrillation in combination with acute coronary syndrome in real clinical practice according to register of acute coronary syndrome in the Krasnodar region</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3868-8061</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Татаринцева</surname><given-names>З. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Tatarintseva</surname><given-names>Z. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Татаринцева Зоя Геннадьевна — заведующая отделением, врач-кардиолог второй категории.</p><p>Краснодар, +7 (903) 452-58-38</p></bio><bio xml:lang="en"><p>Tatarintseva Zoya Gennadievna - Head of the Department of the Main Research Institute of Scientific Research Institute of KKB number 1 named.</p><p>SV Ochapovsky, Krasnodar, ul. 1 Maya, 167, doctor-cardiologist of the second category, telephone +7 (903) 4525838</p></bio><email xlink:type="simple">tatarintsev_m@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5690-2482</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Космачева</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Kosmacheva</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Космачева Елена Дмитриевна — заместитель главного врача по лечебной части, доктор медицинских наук, профессор, заведующая кафедрой терапии № 1 ФПК и ППС ФБОУ ВО КубГМУ.</p></bio><bio xml:lang="en"><p>Kosmacheva Elena Dmitrievna - doctor of medical science, professor, head of the department of therapy № 1 FPK and PPS GBOU KubGMU, deputy Chief Physician for the medical part of the SBU NII-KKB number 1 named. S.V. Ochapovsky.</p><p>Krasnodar</p></bio><email xlink:type="simple">kosmachova_h@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2732-2133</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Порханов</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Porhanov</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук, академик РАН, главный врач.</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Porkhanov Vladimir Alekseevich - doctor of medical sciences, academician of the Russian Academy of Sciences, chief physician of the Institute of Cardiology NII-KKB number 1 named. S.V. Ochapovsky.</p><p>Krasnodar</p></bio><email xlink:type="simple">kkb1@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7538-0437</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кручинова</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kruchinova</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кручинова София Владимировна — врач­-кардиолог, аспирант кафедры терапии № 1 ФПК и ППС ФБОУ ВО КубГМУ.</p><p>Краснодар</p></bio><bio xml:lang="en"><p>Kruchinova S. Vladimirovna - postgraduate student of the department of therapy № 1 FPK and PPS GBOU KubGMU, cardiologist GBUZ NII-KKB number 1 im.prof. S.V. Ochapovsky.</p><p>Krasnodar</p></bio><email xlink:type="simple">skruchinova@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ГБУЗ Научно-исследовательский институт — Краевая Клиническая больница № 1 им. проф. С. В. Очаповского</institution></aff><aff xml:lang="en"><institution>GBUZ Research Institute Regional-Clinical Hospital № 1 named after. S.V. Ochapovsky</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>17</day><month>04</month><year>2019</year></pub-date><volume>18</volume><issue>2</issue><fpage>20</fpage><lpage>25</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Татаринцева З.Г., Космачева Е.Д., Порханов В.А., Кручинова С.В., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Татаринцева З.Г., Космачева Е.Д., Порханов В.А., Кручинова С.В.</copyright-holder><copyright-holder xml:lang="en">Tatarintseva Z.G., Kosmacheva E.D., Porhanov V.A., Kruchinova S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/868">https://cardiovascular.elpub.ru/jour/article/view/868</self-uri><abstract><sec><title>Цель</title><p>Цель. Оценка у пациентов с острым коронарным синдромом (ОКС) в сочетании с фибрилляцией предсердий (ФП) по данным тотального регистра ОКС по Краснодарскому краю эхокардиографических (ЭхоКГ) параметров, а именно размера левого предсердий (ЛП), толщины стенки левого желудочка (ТС ЛЖ), конечного диастолического размера левого желудочка (КДР ЛЖ), фракции выброса левого желудочка (ФВ ЛЖ), величины систолического давления в легочной артерии (СДЛА), а также оценка коронарного субстрата по данным коронароангиографии (КАГ) и определение связи между величиной ФВ ЛЖ и коронарным субстратом.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Из регистра ОКС по Краснодарскому краю были взяты для анализа результаты обследования пациентов, последовательно поступивших в кардиологические отделения ГБУЗ НИИ-ККБ № 1 им. проф. С. В. Очаповского за период времени с 20 ноября 2015г по 20 ноября 2017г с диагнозом ОКС, сопровождающимся одним из типов ФП: пароксизмальной, персистирующей или постоянной. Эта группа пациентов была обозначена как группа ОКС+ФП, в нее вошли 119 пациентов. Группа сравнения была отобрана при помощи генератора случайных чисел из пациентов, поступивших в ГБУЗ НИИ-ККБ № 1 с ОКС и сохранившимся синусовым ритмом (СР) (ОКС+СР), за период времени с 20 ноября 2015г по 20 ноября 2017г она составила 120 пациентов, что равноценно по количеству с исследуемой группой. Анализировали ЭхоКГ параметры, коронарный субстрат по результатам КАГ. Контакт с пациентами осуществлялся при плановых визитах и посредством телефонных звонков. Срок наблюдения составил 6-24 мес. в зависимости от срока включения в регистр.</p></sec><sec><title>Результаты</title><p>Результаты. При сравнении когорты пациентов ОКС+ФП с когортой пациентов ОКС+СР выявлено достоверно значимое (р&lt;0,05) различие размеров ЛП, ФВ ЛЖ, максимальной ТС ЛЖ и величины СДЛА. При сравнении наличия гемодинамически значимых стенозов в коронарных артериях в зависимости от величины ФВ ЛЖ в сравниваемых группах выяснилось, что в когорте пациентов с ОКС+ФП при ФВ ЛЖ &lt;40% в достоверно большем проценте случаев (р=0,0007) встречаются гемодинамические значимые стенозы коронарных артерий в отличие от группы пациентов с ОКС+СР при ФВ ЛЖ &lt;40%. Напротив, при ФВ &gt;40% достоверно чаще (р&lt;0,001) гемодинамически значимые стенозы встречались в группе пациентов с ОКС+СР.</p></sec><sec><title>Заключение</title><p>Заключение. Результаты исследования продемонстрировали ухудшение ряда ЭхоКГ показателей у пациентов с ОКС+ФП. Выявлена связь между ФВ ЛЖ и коронарным субстратом, диагностируемым при КАГ, у пациентов с ОКС+ФП и ОКС + СР, а также между размером ЛП и неблагоприятными исходами у больных ОКС+ФП. Прогностическую значимость выявленных факторов необходимо подтвердить в будущих проспективных исследованиях.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. To evaluate patients with acute coronary syndrome (ACS) in combination with atrial fibrillation (AF) according to the total register of ACS in the Krasnodar region of echocardiographic (EchoCG) parameters (left atrial dimension (LAD), left ventricular wall thickness (LVWT), left ventricle end-diastolic diameter (LVEDD), left ventricular ejection fraction (LVEF), pulmonary artery systolic pressure (PASP), as well as coronary substrate assessment according to coronary angiography (CAG) and determination of the relationship between the value of LVEF and the coronary substrate.</p></sec><sec><title>Material and methods</title><p>Material and methods. From the register of the ACS in the Krasnodar region, patients were successively taken to the cardiology departments of Krasnodar regional clinical hospital № 1 for the period from November 20, 2015 to November 20, 2017 with a diagnosis of ACS, accompanied by one of the types of atrial fibrillation. This group of patients was designated as a group of ACS + AF and amounted to 119 patients. The comparison group was selected with the help of a random number generator from patients admitted to the hospital with ACS and intact sinus rhythm (SR) for the period of time from November 20, 2015 to November 20, 2017 (120). We analyzed the ECHO-CG parameters, the coronary substrate — according to the CAG.</p></sec><sec><title>Results</title><p>Results. When comparing the cohort of patients with ACS + AF with the cohort of patients with ACS + SR, we determined a significant (p&lt;0,05) difference of LA size, LVEF and values of PASP. During comparing the presence of hemodynamically significant stenosis in the coronary arteries we noticed that in ACS + AF patients with LVEF &lt;40% in significantly higher percentage of cases (p=0,0007) occurs significant hemodynamic stenosis of coronary arteries, in contrast to the group of patients with ACS + SR with LVEF &lt;40%. In patients with EF &gt;40% and ACS + SR we determined a significantly more frequent (p&lt;0,001) stenosis.</p></sec><sec><title>Conclusion</title><p>Conclusion. The results of the analysis are important for understanding the distinguishing characteristics of patients with ACS that occur on the background of AF, which is important for correct prediction of the course of the disease. The maintenance of the ACS register will provide information on the real clinical course of the disease, as well as improve the effectiveness of treatment in real clinical practice.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острый коронарный синдром</kwd><kwd>фибрилляция предсердий</kwd><kwd>коронароангиография</kwd><kwd>эхокардиография</kwd><kwd>регистр</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute coronary syndrome</kwd><kwd>atrial fibrillation</kwd><kwd>coronary angiography</kwd><kwd>echocardiography</kwd><kwd>register</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chaga SS, Havmoeller R, Narayanan K, Sing D, et al. World epidemiology of atrial fibrillation: a global burden of disease research, 2010. Circulation. 2014;129:837-47. doi:10.1161/CIRCULATIONAHA.113.005119.</mixed-citation><mixed-citation xml:lang="en">Chaga SS, Havmoeller R, Narayanan K, Sing D, et al. World epidemiology of atrial fibrillation: a global burden of disease research, 2010. Circulation. 2014;129:837-47. doi:10.1161/CIRCULATIONAHA.113.005119.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Miyasaka Y, Barnes ME, Bailey KR, et al. Mortality trends in patients diagnosed with first atrial fibrillation: a 21-year community-based study. JACC. 2007;49:986-92. doi:10.1016/j.jacc.2006.10.062.</mixed-citation><mixed-citation xml:lang="en">Miyasaka Y, Barnes ME, Bailey KR, et al. Mortality trends in patients diagnosed with first atrial fibrillation: a 21-year community-based study. JACC. 2007;49:986-92. doi:10.1016/j.jacc.2006.10.062.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Soliman EZ, Lopez F, O'Neal WT, et al. Atrial Fibrillation and Risk of ST-Segment-Elevation Versus Non-ST-Segment-Elevation Myocardial Infarction: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 2015;131(21):1843-50. doi:10.1161/CIRCULATIONAHA.114.014145.</mixed-citation><mixed-citation xml:lang="en">Soliman EZ, Lopez F, O'Neal WT, et al. Atrial Fibrillation and Risk of ST-Segment-Elevation Versus Non-ST-Segment-Elevation Myocardial Infarction: The Atherosclerosis Risk in Communities (ARIC) Study. Circulation. 2015;131(21):1843-50. doi:10.1161/CIRCULATIONAHA.114.014145.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Soliman EZ, Safford MM, Muntner P, et al. Atrial fibrillation and the risk of myocardial infarction. JAMA Intern Med. 2014;174:107-14. doi: 10.1001/jamainternmed.2013.11912.</mixed-citation><mixed-citation xml:lang="en">Soliman EZ, Safford MM, Muntner P, et al. Atrial fibrillation and the risk of myocardial infarction. JAMA Intern Med. 2014;174:107-14. doi: 10.1001/jamainternmed.2013.11912.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jabre P, Roger VL, Murad MH, et al. Mortality associated with atrial fibrillation in patients with myocardial infarction: a systematic review and meta-analysis. Circulation. 2011;123:1587-93. doi:10.1161/CIRCULATIONAHA.110.986661. Epub 2011.</mixed-citation><mixed-citation xml:lang="en">Jabre P, Roger VL, Murad MH, et al. Mortality associated with atrial fibrillation in patients with myocardial infarction: a systematic review and meta-analysis. Circulation. 2011;123:1587-93. doi:10.1161/CIRCULATIONAHA.110.986661. Epub 2011.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Jabre P, Jouven X, Adnet F, et al. Atrial fibrillation and death after myocardial infarction: a community study. Circulation. 2011;123:2094-100. doi:10.1161/CIRCULATIONAHA.110.990192. Epub 2011.</mixed-citation><mixed-citation xml:lang="en">Jabre P, Jouven X, Adnet F, et al. Atrial fibrillation and death after myocardial infarction: a community study. Circulation. 2011;123:2094-100. doi:10.1161/CIRCULATIONAHA.110.990192. Epub 2011.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Schmitt J, Duray G, Gersh BJ, et al. Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications. Eur Heart J. 2009;30:1038-45. doi:10.1093/eurheartj/ehn579. Epub 2008.</mixed-citation><mixed-citation xml:lang="en">Schmitt J, Duray G, Gersh BJ, et al. Atrial fibrillation in acute myocardial infarction: a systematic review of the incidence, clinical features and prognostic implications. Eur Heart J. 2009;30:1038-45. doi:10.1093/eurheartj/ehn579. Epub 2008.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Шульман В. А., Шестерня П. А., Головенкин С. Е. и др. Фибрилляция предсердий у больных инфарктом миокарда: предикторы возникновения, влияние на ближайший и отдаленный прогноз. Вестник аритмологии. 2005;39:5-9.</mixed-citation><mixed-citation xml:lang="en">Shulman VA, Shesternya PA, Golovenkin SE, et al. Atrial fibrillation in patients with myocardial infarction: predictors of occurrence, impact on the nearest and longterm prognosis. Herald of arrhythmology. 2005;39:5-9. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Lippi G, Picanza A, Formentini A, et al. The concentration of troponin I is increased in patients with acute-onset atrial fibrillation. Int J Cardiol. 2014;173:579-80. doi:10.1016/j.ijcard.2014.03.113. Epub 2014.</mixed-citation><mixed-citation xml:lang="en">Lippi G, Picanza A, Formentini A, et al. The concentration of troponin I is increased in patients with acute-onset atrial fibrillation. Int J Cardiol. 2014;173:579-80. doi:10.1016/j.ijcard.2014.03.113. Epub 2014.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Lang RM, Bierig M, Devereux RB, et al. Recommendations for the quantification of chambers: a report of the Committee on Standards and Standards of the American Society for the Assessment of Echocardiography and the Chamber's quantitative assessment team, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440-63.</mixed-citation><mixed-citation xml:lang="en">Lang RM, Bierig M, Devereux RB, et al. Recommendations for the quantification of chambers: a report of the Committee on Standards and Standards of the American Society for the Assessment of Echocardiography and the Chamber's quantitative assessment team, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr. 2005;18:1440-63.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">McCullough PA, Gibson CM, Dibattiste PM, et al. Timing of angiography and revascularization in acute coronary syndromes: an analysis of the TACTICS-TIMI-18 trial. J Interv Cardiol. 2004;17(2):81-6. doi:10.1111/j.1540-8183.2004.021001.x.</mixed-citation><mixed-citation xml:lang="en">McCullough PA, Gibson CM, Dibattiste PM, et al. Timing of angiography and revascularization in acute coronary syndromes: an analysis of the TACTICS-TIMI-18 trial. J Interv Cardiol. 2004;17(2):81-6. doi:10.1111/j.1540-8183.2004.021001.x.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bahouth F, Mutlak D, Furman M, et al. Relationship of functional mitral regurgitation to new-onset atrial fibrillation in acute myocardial infarction. Heart. 2010;96:683-8. doi:10.1136/hrt.2009.183822.</mixed-citation><mixed-citation xml:lang="en">Bahouth F, Mutlak D, Furman M, et al. Relationship of functional mitral regurgitation to new-onset atrial fibrillation in acute myocardial infarction. Heart. 2010;96:683-8. doi:10.1136/hrt.2009.183822.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Aronson D, Mutlak D, Bahouth F, et al. Restrictive left ventricular filling pattern and risk of new-onset atrial fibrillation after acute myocardial infarction. Am J Cardiol. 2011;107:1738-43. doi:10.1016/j.amjcard.2011.02.334. Epub 2011.</mixed-citation><mixed-citation xml:lang="en">Aronson D, Mutlak D, Bahouth F, et al. Restrictive left ventricular filling pattern and risk of new-onset atrial fibrillation after acute myocardial infarction. Am J Cardiol. 2011;107:1738-43. doi:10.1016/j.amjcard.2011.02.334. Epub 2011.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
