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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">cardiovascular</journal-id><journal-title-group><journal-title xml:lang="ru">Кардиоваскулярная терапия и профилактика</journal-title><trans-title-group xml:lang="en"><trans-title>Cardiovascular Therapy and Prevention</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1728-8800</issn><issn pub-type="epub">2619-0125</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.15829/1728-8800-2018-4-26-33</article-id><article-id custom-type="elpub" pub-id-type="custom">cardiovascular-886</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИШЕМИЧЕСКАЯ БОЛЕЗНЬ СЕРДЦА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CORONARY HEART DISEASE</subject></subj-group></article-categories><title-group><article-title>Влияние табакокурения на клиническую эффективность годичной реабилитационной программы после острого инфаркта миокарда у больных ишемической болезнью сердца трудоспособного возраста</article-title><trans-title-group xml:lang="en"><trans-title>Influence of tobacco smoking on clinical efficacy of a 1-year rehabilitation programme for myocardial infarction patients of economically active age</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2250-5942</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бубнова</surname><given-names>М. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Bubnova</surname><given-names>M. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бубнова Марина Геннадьевна — доктор медицинских наук, профессор, руководитель отдела реабилитации и вторичной профилактики сочетанной патологии с лабораторией профилактики атеросклероза и тромбоза.</p></bio><bio xml:lang="en"><p>Moscow</p></bio><email xlink:type="simple">mbubnova@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0484-9805</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Аронов</surname><given-names>Д. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Aronov</surname><given-names>D. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Доктор медицинских наук профессор, заслуженный деятель науки РФ, руководитель лаборатории кардиологической реабилитации отдела реабилитации и вторичной профилактики сочетанной патологии.</p><p>Москва</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8412-4155</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кандидат педагогических наук, старший научный сотрудник лаборатории кардиологической реабилитации.</p></bio><bio xml:lang="en"><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФГБУ “Национальный медицинский исследовательский центр профилактической медицины”  Министерства здравоохранения Российской Федерации</institution></aff><aff xml:lang="en"><institution>National Medical Research Centre of Prevention Medicine of the Ministry of Health</institution></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>20</day><month>08</month><year>2018</year></pub-date><volume>17</volume><issue>4</issue><fpage>26</fpage><lpage>33</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бубнова М.Г., Аронов Д.М., Новикова Н.К., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Бубнова М.Г., Аронов Д.М., Новикова Н.К.</copyright-holder><copyright-holder xml:lang="en">Bubnova M.G., Aronov D.M., Novikova N.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://cardiovascular.elpub.ru/jour/article/view/886">https://cardiovascular.elpub.ru/jour/article/view/886</self-uri><abstract><sec><title>Цель</title><p>Цель. Изучение эффективности годичной программы физических тренировок (ФТ) у больных ишемической болезнью сердца (ИБС) трудоспособного возраста, перенесших острый инфаркт миокарда (ОИМ), в зависимости от статуса курения.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В исследование включены мужчины (n=338) после ОИМ не ранее 3 нед. от события. В зависимости от статуса курения и участия в ФТ пациенты рандомизированы в 4 группы: больные, вовлеченные в ФТ, — 1 группа (n=84) курящие и 2 группа (n=85) некурящие, 3 группа — больные без ФТ (n=85) курящие и 4 группа (n=84) — некурящие. Все больные получали стандартную медикаментозную терапию. Применялись ФТ в режиме средней интенсивности (50-60% от выполненной мощности при нагрузочной пробе) 3 раза в нед. в течение 1 года.</p></sec><sec><title>Результаты</title><p>Результаты. После ФТ у курящих (n=41) и некурящих (n=85) больных увеличилась длительность нагрузки на 30,3% (p&lt;0,001) и на 28,4% (p&lt;0,001) и ее мощность на 31,2% (p&lt;0,001) и на 30,8% (p&lt;0,001) на фоне повышения на 3,8% (p&lt;0,01) экономичности физической работы, но только у курящих. Без ФТ только у некурящих выявлялось некоторое увеличение длительности нагрузки на 10,1% (p&lt;0,01) и ее мощности на 11,1% (p&lt;0,05), но в меньшей степени, а у курящих пациентов, напротив, показатель экономичности выполненной работы снижался на 13,3% (p&lt;0,05). Это сочеталось с уменьшением размеров сердца и  повышением фракции выброса левого желудочка у курящих и в большей степени у некурящих; при отсутствии ФТ изменений не было, за исключением некоторого (на 1,9%) (p&lt;0,05) роста фракции выброса левого желудочка у  некурящих. Только на фоне ФТ в равной степени у курящих и некурящих пациентов снижались уровни атерогенных липидов крови и повышался холестерин липопротеидов высокой плотности. После 1 года ФТ развитие всех случаев сердечно-сосудистых осложнений достоверно уменьшилось у курящих на 44,8% (р&lt;0,05) и некурящих на 50,9% (р&lt;0,05).</p></sec><sec><title>Заключение</title><p>Заключение. Длительные (годичные) ФТ средней интенсивности как у курящих, так и некурящих больных, перенесших ОИМ, обеспечивают стабильное течение заболевания, уменьшают развитие сердечно-сосудистых осложнений и  улучшают качество жизни пациента. Однако фактор “курения” снижает реабилитационный потенциал пациента и препятствует достижению лучших результатов при кардиореабилитации.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Aim</title><p>Aim. Evaluation of the efficacy of 1-year exercise based program (EP) in coronary heart disease (CHD) patients of economically active age after acute myocardial infarction (MI), depending on smoking status.</p></sec><sec><title>Material and methods</title><p>Material and methods. To the study, males included (n=338) after MI (not later than 3 weeks from the event). Four groups shaped by randomization: EP patients smokers (group 1, n=84), EP non-smokers (group 2, n=85); no EP smokers (group 3, n=85) and no EP non-smokers (group 4, n=84). All patients received standard medication treatment. The EP were added, of moderate intensity (50-60% from the load in exercise test) 3 times a week during 1 year.</p></sec><sec><title>Results</title><p>Results. After EP in smokers (n=41) and non-smokers (n=85) there was an increase of load duration by 30,3% (p&lt;0,001) and by 28,4% (p&lt;0,001), and its intensity by 31,2% (p&lt;0,001) and 30,8% (p&lt;0,001), with 3,8% (p&lt;0,01) increase of economicity of physical work, but only in smokers. With no EP only in non-smokers there was slight increase of exercise duration by 10,1% (p&lt;0,01) and its intensity by 11,1% (p&lt;0,05), but milder, and in smokers, in contrary, the economicity parameter declined by 13,3% (p&lt;0,05). This was linked with the heart size enlargement and the left ventricle ejection fraction increase in smokers and non-smokers; in the absence of EP there were no changes, just slight (by 1,9%) (p&lt;0,05) increase of the left ventricle ejection fraction in non-smokers. Only at EP, with similar grade in smokers and non-smokers there was decrease of atherogenic lipids levels and high density cholesterol increase. In 1 year of EP, all cases of cardiovascular adverse events significantly decreased in smokers by 44,8% (р&lt;0,05) and in nonsmokers by 50,9% (р&lt;0,05).</p></sec><sec><title>Conclusion</title><p>Conclusion. Long term (1 year) EP of moderate intensity, in both smokers and non-smokers MI patients lead to stable disease course, decrease the rate of cardiovascuar complications and improve patients life quality. However the “smoking factor” decreases rehabilitational potentional of patient and interferes with better results achievement in cardiorehabilitation.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>острый инфаркт миокарда</kwd><kwd>кардиореабилитация</kwd><kwd>физические тренировки</kwd><kwd>курение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute myocardial infarction</kwd><kwd>cardiorehabilitation</kwd><kwd>exercise training</kwd><kwd>smoking</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">ФГБУ “НМИЦ ПМ” Минздрава России, № гос. регистрации: 115072340037</funding-statement><funding-statement xml:lang="en">State Assignment to the Institution, № 115072340037</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Timmis A, Townsend N, Gale C, et al. European Society of Cardiology: Cardiovascular Disease Statistics 2017. 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