cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2018-6-110-116cardiovascular-896Research ArticleОБЗОРЫREVIEWSРоль нейтрофилов в патогенезе атеросклерозаThe role of neutrophils in the pathogenesis of atherosclerosishttps://orcid.org/0000-0002-2697-7317СаранчинаЮ. В.SaranchinaYu. V.

Саранчина Юлия Владимировна — кандидат биологических наук, доцент кафедры фундаментальной медицины и гигиены.

Абакан

Abakan

july.saran4ina2010@yandex.ruhttps://orcid.org/0000-0002-1849-7735ДутоваС. В.DutovaS. V.

Дутова Светлана Вячеславовна — доктор фармакологических наук, доцент кафедры фундаментальной медицины и гигиены.

Абакан

Abakan

coluria@mail.ruhttps://orcid.org/0000-0002-8862-3282КилинаО. Ю.KilinaO. Yu.

Abakan

okilina@mail.ruhttps://orcid.org/0000-0002-4850-1627ХанаринН. В.KhanarinN. V.

Ханарин Николай Владимирович — кандидат медицинских наук, доцент кафедры общепрофессиональных дисциплин.

Abakan

hanarinn@yandex.ruhttps://orcid.org/0000-0002-9528-2535КулаковаТ. С.KulakovaT. S.

Кулакова Татьяна Сергеевна — ординатор кафедры внутренних болезней.

Абакан

Abakan

hardinatatyana@mail.ruФГБОУ ВО Хакасский государственный университет им. Н.Ф. КатановаN.F. Katanov Khakassian State University201820122018176110116Copyright © Саранчина Ю.В., Дутова С.В., Килина О.Ю., Ханарин Н.В., Кулакова Т.С., 20182018Саранчина Ю.В., Дутова С.В., Килина О.Ю., Ханарин Н.В., Кулакова Т.С.Saranchina Y.V., Dutova S.V., Kilina O.Y., Khanarin N.V., Kulakova T.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/896

Атеросклероз (АС) является одной из причин сердечно-сосудистых заболеваний. Формирование атеросклеротического поражения артерий — длительный процесс, а клинические симптомы проявляются уже на стадии атеросклеротической бляшки, которая стенози-руя сосуд, препятствует кровотоку, и может вызвать ишемическую болезнь сердца, а также острый коронарный синдром. В связи с чем, изучение механизмов АС на субклиническом уровне является актуальным. В представленной статье приводятся обобщенные современные данные о строении и функциях нейтрофилов (НФ) в физиологических процессах. Особое внимание в обзоре уделено участию НФ в повреждении и формировании дисфункции эндотелия сосудов как одного из основных звеньев патогенеза АС. Обсуждается несколько возможных механизмов участия НФ в ате-рогенезе: продукция активных форм кислорода, вызывающих непосредственное повреждение эндотелия; синтез цитокинов, активирующих миграцию лейкоцитов в очаг воспаления; образование белковых комплексов с холестерином, способствующих их отложению в сосудах, и формирование нейтрофильных ловушек, запускающих деструктивно-альтеративные реакции.

Atherosclerosis (AS) is one of the causes of cardiovascular disease. The formation of atherosclerotic lesions of the arteries is a long process, and clinical symptoms appear already at the stage of atherosclerotic plaque (ASB), which prevents blood flow and can cause coronary heart disease, as well as acute coronary syndrome. The study of atherosclerosis mechanisms at the subclinical level is relevant. This article provides a summary of current data on the structure and functions of neutrophils (NF) in physiological processes. Particular attention is paid to the participation of neutrophils in the damage and formation of vascular endothelial dysfunction. Discusses several mechanisms of involvement of neutrophils in atherogenesis: the production of reactive oxygen species, which cause direct endothelial damage; the synthesis of cytokines that trigger the migration of leukocytes in inflammation; the formation of protein complexes with cholesterol, contributing to their deposition in the vessels, and neutrophil traps, triggering destructive-alterative reactions.

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The authors declare that there are no conflicts of interest present.