cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-917Research ArticleОБЗОР ЛИТЕРАТУРЫLITERATURE REVIEWНовые возможности в лечении ишемической болезни сердцаNew perspectives in coronary heart disease managementМаколкинВ. И.MakolkinV. I.dvmak@mail.ruМосковская медицинская академия имени И.М.Сеченова, МоскваI.M. Sechenov Moscow Medical Academy, Moscow200520022005419095Copyright © Маколкин В.И., 20052005Маколкин В.И.Makolkin V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/917

Статья посвящена проблеме применения ингибиторов ангиотензин-превращающего фермента (иАПФ) при лечении стабильных форм ишемической болезни сердца (ИБС). Она содержит сведения о результатах, полученных в многоцентровых исследованиях, посвященных эффективности различных иАПФ для снижения риска общей смертности, вероятности развития фатального и нефатального инфаркта миокарда, мозгового инсульта, хронической сердечной недостаточности у больных ИБС. Эффективность иАПФ при ИБС связывают с влиянием препарата на эндотелиальную дисфункцию, факторы тромбоза и воспаления, увеличение продукции брадикинина, повышение активности NO-синтетазы. Недавно завершенное исследование EUROPA продемонстрировало, что периндоприл в дозе 8 мг/сут может быть рекомендован больным для терапии стабильной формы ИБС.

The article is devoted to ACE inhibitor therapy in stable coronary heart disease (CHD). The author analyzes the results of multi-center trials on various ACE inhibitors’ efficacy in decreasing risk of all-cause mortality, fatal and non-fatal myocardial infarction, stroke, chronic heart failure in CHD patients. ACE inhibitor efficacy in CHD is explained by the influence on endothelial dysfunction, thrombosis and inflammation factors, increased bradykinin synthesis and NO-synthase activity. A new trail EUROPA demonstrated that perindopril (8 mg/d) could be recommended to patients with stable CHD.

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The authors declare that there are no conflicts of interest present.