cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLC10.15829/1728-8800-2013-6-21-23cardiovascular-95Research ArticleМНЕНИЕ ПО ПРОБЛЕМЕOPINION ON A PROBLEM“ВНЕЦЕЛЕВЫЕ” ЭФФЕКТЫ ИНГИБИТОРОВ АНГИОТЕНЗИН-ПРЕВРАЩАЮЩЕГО ФЕРМЕНТА: БОЛЬШЕ ПРЕИМУЩЕСТВ В ТЕРАПИИOFF-TARGET EFFECTS OF ANGIOTENSIN-CONVERTING ENZYME INHIBITORS: ADDITIONAL THERAPEUTIC BENEFITSШайдюкО. Ю.ShaidyukO. Yu.

кардиолог, доцент кафедры госпитальной терапии № 1 лечебного факультета

ТаратухинЕ. О.TaratukhinE. O.

кардиолог, к.м.н., ассистент кафедры госпитальной терапии № 1 лечебного факультета

Тел.: +79166372978 

tel.: +79166372978 

cardio03@list.ruГБОУ ВПО Российский национальный исследовательский медицинский университет им. Н.И. Пирогова Минздрава России, МоскваN.I. Pirogov Russian National Medical Research University, Moscow2013201220131262123Copyright © Шайдюк О.Ю., Таратухин Е.О., 20132013Шайдюк О.Ю., Таратухин Е.О.Shaidyuk O.Y., Taratukhin E.O.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/95

Статья посвящена дополнительным, “внецелевым”, или “off-target” эффектам ингибиторов ангиотензин-превращающего фермента (ИАПФ), в частности, зофеноприла. Это новое поле исследования фармакопрепаратов, и антигипертензивные средства — не исключение. Приводятся данные о возможном взаимодействии ИАПФ и ацетилсалициловой кислоты, результаты международных многоцентровых исследований.

The paper is focused on additional, or off-target, effects of angiotensinconverting enzyme inhibitors (ACEI), zofenopril in particular. This is a new area in the pharmacological research, which is also relevant to antihypertensive agents. The authors present the data on potential interaction between ACEI and acetylsalicylic acid, as well as the results of international multi-centre studies. 

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The authors declare that there are no conflicts of interest present.