cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-976Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESВаскулярные ростовые факторы в патогенезе гипертензивных состоянийVascular growth factors in hypertensive state pathogenesisГомазковО. А.GomazkovO. A.НИИ биомедицинской химии им. В.Н. Ореховича РАМН, МоскваV.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Science, Moscow20052006200543, ч.I93103Copyright © Гомазков О.А., 20052005Гомазков О.А.Gomazkov O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/976

Обобщение и анализ информации о роли нейротрофических и ростовых факторов в формировании сосудистой патологии, артериальной гипертонии (АГ) и органных поражений (ОП) позволяет определить новые позиции терапевтической стратегии. Становится все более очевидным, что помимо систем пептидных регуляторов (ангиотензин II, эндотелин-1, атриальные натрийуретические факторы), катехоламинов и др. в патогенезе кардиоваскулярных расстройств принимают участие полипептидные ростовые и нейротрофические факторы, встроенные в общую систему химической регуляции. Они выполняют функцию регуляторов нормальных и дисбалансированных процессов и непосредственно причастны к триаде «окислительные стресс – воспаление – эндотелиальная дисфункция», служащей основой развития АГ и ОП. Среди этих факторов первостепенный интерес представляют: Эндотелиальный фактор роста сосудов, Инсулиноподобные факторы роста, Тромбоцитарный ростовой фактор, Трансформирующие ростовые факторы, Фактор роста фибробластов, Фактор некроза опухоли. Структурные и функциональные особенности этих соединений и их значимость в качестве возможных посредников и/или предикторов и мишеней патологических процессов в сосудистой стенке представлены в настоящей статье.

Summarizing and analyzing the information on the role of neurotrophic and growth factors in vascular pathology, arterial hypertension (AH), and organ damage (OD) pathogenesis, enables us to set new targets for treatment strategy. It is more and more evident that, besides the systems of peptide regulators (angiotensin II, endothelin-1, atrial natriuretic factors), catecholamines, etc., cardiovascular pathology pathogenesis is influenced by polypeptide growth and neurotrophic factors, participating in the complex chemical regulation process. They act as regulators of normal and pathological processes, and are directly linked with the triade “oxidative stress-inflammation-endothelial dysfunction”, that is crucial in AH and OD pathogenesis. Among these factors, the most prospective are: endothelial vascular growth factor, insulin-like growth factors, platelet growth factor, transforming growth factors, fibroblast growth factor, tumor necrosis factor. Structural and functional features of these substances, together with their role as possible mediators and/or predictors and targets in vascular pathology processes, are described in this article.

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The authors declare that there are no conflicts of interest present.