cardiovascularКардиоваскулярная терапия и профилактикаCardiovascular Therapy and Prevention1728-88002619-0125«SILICEA-POLIGRAF» LLCcardiovascular-993Research ArticleОБЗОРЫ ЛИТЕРАТУРЫREVIEW ARTICLESОдновременное ингибирование всасывания и синтеза холестерина при сочетанном применении эзетимиба и симвастатинаSimultaneous inhibition of cholesterol absorption and synthesis in combined therapy with ezetimibe and simvastatinАроновД. М.AronovD. M.oganov@online.ruГосударственный научно-исследовательский центр профилактической медицины Росздрава, МоскваState Research Center for Preventive Medicine, Ministry of Health of the Russian Federation, Moscow2005200820054491100Copyright © Аронов Д.М., 20052005Аронов Д.М.Aronov D.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://cardiovascular.elpub.ru/jour/article/view/993

Обзор посвящен фармакологической характеристике, механизму действия, гиполипидемической активности и плеотропным эффектам нового гиполипидемического средства эзетимиба, ингибирующего абсорбцию холестерина кишечником. Особое внимание уделено работам, в которых эзетимиб применялся в сочетании с другими гиполипидемическими средствами (статинами, фибратами, секвестрантами желчных кислот). Показано, что начальная доза разных статинов в сочетании с 1 таблеткой (10 мг) эзетимиба снижают уровень холестерина липопротеинов низкой плотности в такой же степени, что и максимальная доза статина.

This review is devoted to pharmacological characteristics, action mechanisms, hypolipidemic activity, and pleiotropic effects of a new hypolipidemic medication – ezetimibe, inhibiting intestinal cholesterol absorption. The combination of ezetimibe with other hypolipidemic drugs (statins, fibrates, bile acid sequestrants) is described in detail. Initial doses of various statins, together with one tablet (10 mg) of ezetimibe, reduce low-density cholesterol level as effectively as maximal statin doses.

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The authors declare that there are no conflicts of interest present.