Cerebrovascular events primary prevention in metabolic syndrome patients
Abstract
Aim. To study effects of therapy with bisoprolol (Concor®) and deproteinized hemoderivate (Actovegin®) on circadian blood pressure profile (CBPP), carbohydrate, lipid metabolism, and cerebral perfusion in patients with metabolic syndrome (MS) and mild arterial hypertension (AH). Material and methods. The study included 30 patients with mild AH and MS: 15 participants received Concor®, 15 - Concor® and Actovegin®, for 12 weeks. All individuals underwent clinical and laboratory examination, as well as cerebral perfusion assessment by single-photon emission computer tomography. Results. In both groups, therapy was associated with significant BP decrease and CBPP normalization, together with neutral metabolic effect. At baseline, cerebral perfusion was reduced in all patients. Actovegin® treatment substantially improved cerebral perfusion. Conclusion. In MS patients, Actovegin® facilitated cerebral perfusion improvement, with neutral metabolic effect.
About the Authors
V. B. Mychka
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development. Moscow
Russian Federation
Russian Federation
K. M. Mamyrbaeva
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development. Moscow
Russian Federation
Russian Federation
V. B. Sergienko
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development. Moscow
Russian Federation
Russian Federation
V. P. Masenko
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development. Moscow
Russian Federation
Russian Federation
I. E. Chazova
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development. Moscow
Russian Federation
Russian Federation
References
1. Чазова И.Е., Мычка В.Б., Мамырбаева К.М. и др. Цереброваскулярные осложнения при метаболическом синдроме: возможные подходы к снижению риска. Тер архив 2004; 6: 29-32.
2. Bertel O, Marx B, Conen D. Effects of antihypertensive treatment on cerebral perfusion. Am J Med 1987; 82-92.
3. Meyer JS, Rogers RL, Mortel RF. Prospective analysis of longterm control of mild hypertension in cerebral blood flow. Stroke 1985; 16(6): 985-90.
4. Hares P, James IM, Griffith D. Effect of acebutolol on cerebral circulation of a man. Br J Clin Pharmacol 1977; 4: 373-5.
5. Верещагин Н.В., Моргунов В.А., Гулевская Т.С., Патология головного мозга при атеросклерозе и артериальной гипертонии. Москва «Медицина» 1997; 237-9
6. Fuijshima M, Ibayashi S, Fugii, K et al. Effects of long-term antihypertensive treatment on cerebral thalamic and cerebral blood flow in spontaneously hypertensive rats SHR. Stroke 1986; 17-5.
7. UK Prospective Diabetes Study Group. Efficacy of atenolol and captopril in reducing risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 39. Br Med J 1998; 317: 713-9.
8. Janka HU, Ziegler AG, Disselhoff G, Mehnert H. Influece of bisiprolol on blood glucose, glucosuria and haemoglobin A1, in non-insulin-dependent diabetics. J Cardivasc Pharmacol 1986; 8 (Suppl. 11): s 96-9.
9. Haneda T, Ido A, Fijikane T, et al. Effect of bisoprolol, a β1 -selective β-blocer, on lipid and glucose metabolism and quality of life in elderly patients with essential hypertension. Jpn J Geriat 1998; 35:33-8.
10. Asmar RG, Kerihuel JC, Girerd XJ, Safar ME. Effect of bisoprolol on blood pressure and arterial hemodinamyc hypertension. Am J Cardiol 1991; 68:61-4.
11. Bell GI, Kanano JB, Buse CF, et al. Molecular biology of mammalian glucose transporters Diabetes Care 1990; 13; 198-208.
12. Cushman SW, Wardzala LJ. Potential mechanism of insulin action on glucose transport in the isolated rat adipose cell. Apparent translocation of intracellular transport systems to the plasma membrane. J Biol Chem 1980; 225; 4758-62.
Review
For citations:
Mychka V.B., Mamyrbaeva K.M., Sergienko V.B., Masenko V.P., Chazova I.E. Cerebrovascular events primary prevention in metabolic syndrome patients. Cardiovascular Therapy and Prevention. 2006;5(2):33-39. (In Russ.)
Views:
567
Email this article 
