Clinical pharmacogenetics of angiotensin II receptor blockers: new perspectives of pharmacotherapy individualization
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Abstract
The review focuses on clinical practice perspectives for angiotensin II receptor blockers (ARB). The authors discuss the results of the trials on biotransformation genes (CYP2C9) polymorphism and renin-angiotensin-aldosterone system influence on ARB pharmacokinetics and pharmacodynamics. Pharmacogenetic studies have been performed not only in healthy volunteers, but also in patients with arterial hypertension or chronic heart failure.
About the Authors
D. A. SychevRussian Federation
G. S. Anikin
Russian Federation
V. G. Belolipetskaya
Russian Federation
I. B. Ignatyev
Russian Federation
V. G. Kukes
Russian Federation
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Review
For citations:
Sychev D.A., Anikin G.S., Belolipetskaya V.G., Ignatyev I.B., Kukes V.G. Clinical pharmacogenetics of angiotensin II receptor blockers: new perspectives of pharmacotherapy individualization. Cardiovascular Therapy and Prevention. 2006;5(2):100-105. (In Russ.)
ISSN 2619-0125 (Online)