Combined effects of antihypertensive medications: computer prognosis
Abstract
Modern concept of arterial hypertension (AH) combined therapy is based on using agents with various pharmacotherapeutic mechanisms of action. Despite the impressive number of clinical trials conducted, the real-life basis for combined therapy is mostly clinician’s empirical experience. Computer program and database PASS (Prediction of Activity Spectra of Substances; website http://www.ibmc.msk.ru/PASS) gives an opportunity to predict potential activity spectra for specific chemical structures. PASS could be used for assessment of: a) main pharmaco-therapeutic effects; b) biochemical mechanisms underlying these effects; c) possible adverse (toxic) effects. Using this approach for some antihypertensives (lisinopril, amlodipine, trandolapril, etc.) provided information on medication action spectra and cellular-biochemical mechanisms. Reliable prognostic data were obtained for additional, unstudied before, pharmaco-therapeutic effects. These vasodilatation-independent effects are linked to chemical structure specifics. PASS program provides clinicians with unique information on potential medication polymodality and adverse effects in treating AH and its complications.
About the Authors
O. A. Gomaskov
V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences. Moscow
Russian Federation
Russian Federation
A. A. Lagunin
V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences. Moscow
Russian Federation
Russian Federation
V. V. Poroykov
V.N. Orekhovich Research Institute of Biomedical Chemistry, Russian Academy of Medical Sciences. Moscow
Russian Federation
Russian Federation
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Review
For citations:
Gomaskov O.A., Lagunin A.A., Poroykov V.V. Combined effects of antihypertensive medications: computer prognosis. Cardiovascular Therapy and Prevention. 2008;7(5):100-104. (In Russ.)
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