Hindlll polymorphism of lipoprotein lipase gene in patients with acute coronary syndrome
Abstract
Aim. To study the role of lipoprotein lipase (LPL) gene HindIII polymorphism in hospital and post-hospital prognosis of acute coronary syndrome (ACS).
Material and methods. The study included 423 ACS patients. In 382 participants with verified myocardial infarction (MI) and unstable angina (UA), LPL gene HindIII polymorphism was analyzed. Hospital and post-hospital (one-year) ACS outcomes were registered.
Results. The prevalence of LPL gene Н+/+, Н+/- and Н-/- genotypes was similar among patients with MI and ST segment elevation (ST-MI) and participants with MI, UAand no ST segment elevation (non-ST-MI). At the same time, among those under 65 years, genotype patterns were different in ST-MI vs. UA patients (df=2, p=0,017), mostly due to high prevalence of Н+/+genotype (77 % and 42 %, respectively). Genotype distribution in non-ST-MI patients could be described as intermediate. Hospital and post-hospital lethality, as well as non-fatal ACS complication rate, was similar in different genotype groups. Lethality risk, calculated by hospital risk scale, was higher in elderly Н+/+ carriers. Age-related increase in post-hospital lethality was typical only for Н+/+ carriers (for every 5 years, adjusted risk of cardiovascular death increased by 2,89 (1,23; 6,76) times). No similar tendency was observed for Н- carriers.
Conclusion. LPL gene Н+/+ genotype was associated with ST-MI, but only in those under 65 years. Elderly carriers of this genotype had relatively high risk of hospital and post-hospital death
About the Authors
R. T. Saygitov
Moscow City Clinical Hospital № 59
Russian Federation
Russian Federation
M. G. Glezer
Moscow City Clinical Hospital № 59;
Research Center, I.M. Sechenov Moscow Medical Academy
Russian Federation
Russian Federation
N. A. Malygina
Russian Research Institute of Gerontology. Moscow
Russian Federation
Russian Federation
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Review
For citations:
Saygitov R.T., Glezer M.G., Malygina N.A. Hindlll polymorphism of lipoprotein lipase gene in patients with acute coronary syndrome. Cardiovascular Therapy and Prevention. 2008;7(8):39-44. (In Russ.)
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