Haemostasiologic effects of various glucose-lowering medications in type 2 diabetes mellitus
Abstract
Aim. To evaluate the effects of insulin and other glucose-lowering medications on platelet function and coagulation haemostasis in patients with Type 2 diabetes mellitus (DM-2). Material and methods. The study included 147 patients with DM-2, aged 49—60 years (mean age 54 years), not receiving any glucose-lowering therapy, or regularly taking various glucose-lowering medications (glibenclamide, gliclazide, metformin, insulin, and glibenclamide + metformin combination). Results. Platelet function activation and increased pro-coagulation activity are typical for DM-2 patients, including individuals at early DM stages, without angiopathy, and not receiving pharmaceutical treatment. Various groups of glucose-lowering medications have different effects on hemostasis parameters. Specifically, insulin, glibenclamide, metformin and glibenclamide + metformin combination do not have any anti-aggregant activity. At the same time, insulin and glibenclamide activate the internal coagulation pathway. Anti-platelet activity of glibenclamide is similar to that of acetylsalicylic acid. Conclusion. Different haemostasiologic effects of glucose-lowering medications should be considered while choosing individual treatment strategy in DM-2 patients.
About the Authors
G. G. Petrik
Kuban State Medical University. Krasnodar
Russian Federation
Russian Federation
S. A. Pavlishchuk
Kuban State Medical University. Krasnodar
Russian Federation
Russian Federation
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Review
For citations:
Petrik G.G., Pavlishchuk S.A. Haemostasiologic effects of various glucose-lowering medications in type 2 diabetes mellitus. Cardiovascular Therapy and Prevention. 2010;9(2):48-53. (In Russ.)
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