Intracardiac and pulmonary hemodynamics and arterial blood gases in patients with chronic stable angina pectoris associated with chronic obstructive pulmonary disease

Aim. To study intracardiac and pulmonary hemodynamics and arterial blood gases in patients with chronic stable angina pectoris associated with chronic obstructive pulmonary disease (COPD).
Material and methods. The study included 103 patients: 49 people with Functional Class II chronic stable angina pectoris and COPD, plus 54 individuals with COPD only. Arterial blood gases, left and right ventricular (LV, RV) diastolic function (echocardiography with colour Doppler ultrasound), and right heart pressure levels (right heart and pulmonary artery (PA) catheterisation) were assessed.
Results. The patients with chronic stable angina pectoris associated with COPD were characterised by progressing RV and LV diastolic dysfunction. In contrast to patients with isolated COPD, RV diastolic dysfunction was more pronounced in participants with combined pathology. In both groups, pulmonary hemodynamics was characterised by equivalent increases in systolic, diastolic, and mean PA pressure (Stage I). The manifestations of this increase were determined by the COPD stage.
Conclusion. Combined cardio-respiratory pathology was characterised by progressing RV andLV diastolic dysfunction. In both groups, the factors with the strongest correlation with pulmonary hypertension included arterial hypoxemia, hypercapnia, and RV diastolic dysfunction.

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