Diagnostic and prognostic role of PAPP-A and inflammatory markers in various forms of coronary heart disease
Abstract
Aim. To measure the blood levels of pregnancy-associated plasma protein A (PAPP-A) and inflammatory markers in patients with various forms of coronary heart disease (CHD); to evaluate their diagnostic and prognostic role. Material and methods. The study included 75 patients with unstable angina (UA), acute myocardial infarction (AIM), and stable angina. The concentrations of PAPP-A, vascular adhesion molecule (sVCAM-1) and interleukin-6 (IL-6) were measured by immuno-enzyme method; the levels of C-reactive protein (CRP) and fibrinogen were measured by latex-enhanced micro-plate immuno-turbidimetry method. The follow-up period lasted for two years. Results. A significant elevation of PAPP-A, CRP, IL-6, and sVCAM1 levels was observed in UA and AMI patients. The level of PAPP-A was significantly higher in UA participants than in those with AMI, and demonstrated the highest sensitivity and specificity in UA diagnostics. Conclusion. PAPP-A could be used as a marker of acute coronary syndrome. Its elevated levels (>10mIU/l) predict adverse outcomes in CHD patients.
About the Authors
A. O. Shevchenko
Russian State Medical University
Russian Federation
Russian Federation
Yu. S. Slesareva
Russian State Medical University
Russian Federation
Russian Federation
S. Al-Bustani
Russian Medical Academy of Post-Diploma Medical Education. Moscow
Russian Federation
Russian Federation
A. V. Bugrov
V.I. Shumakov Federal Research Centre of Transplantology and Artificial
Organs
Russian Federation
Russian Federation
O. P. Shevchenko
Russian State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Shevchenko A.O., Slesareva Yu.S., Al-Bustani S., Bugrov A.V., Shevchenko O.P. Diagnostic and prognostic role of PAPP-A and inflammatory markers in various forms of coronary heart disease. Cardiovascular Therapy and Prevention. 2010;9(3):23-28. (In Russ.)
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