Role of air pollution by particulate matter in the pathogenesis of cardiovascular diseases. Prevention measures
https://doi.org/10.15829/1728-8800-2020-2421
Abstract
The review highlights contemporary concepts about the role of atmospheric air pollution by particulate matter (PM) in pathogenesis of cardiovascular diseases (CVD). We used publications from the PubMed and Russian Science Citation Index databases. The influence of PM on the development and progression of CVD is considered depending on size, origin, chemical composition, concentration in air. PM with an aerodynamic diameter of ≤2,5 μm (PM2,5) are recognized as the most dangerous. Epidemiological studies have established a dose-dependent effect PM. Oxidative stress, damage of genome of cell and epigenetic changes associated with PM effect are the important component of CVD pathogenesis. Systematization of scientific data through a formalized description helps to understand the pathogenesis of CVD and facilitates its practical use for assessing the risk of occurrence, early diagnosing, prognostication, increasing the effectiveness of treatment, and developing preventive measures.
Keywords
air pollution,
particulate matter,
pathogenesis,
cardiovascular diseases,
preventive measures,
review
Supporting agencies: ICT SB RAS, Novosibirsk
About the Authors
A. F. Kolpakova
Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Kolpakova Alla F. — MD, Professor, Leading Researcher of laboratory for modeling geoecological systems of ICT SB RAS
Novosibirsk
SPIN 6318-0028
R. N. Sharipov
LLC BIOSOFT.RU;
Novosibirsk State University
Russian Federation
Russian Federation
Sharipov Ruslan N. — Project Manager, BIOSOFT.RU, LLC; Senior Lecturer, SESC of NSU
Novosibirsk
SPIN 1214-2918
O. A. Volkova
Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Volkova Oxana A. — PhD, researcher of Laboratory of Genetic Engineering, FIC Institute of Cytology and Genetics, SB RAS
Novosibirsk
SPIN 8803-1300
F. A. Kolpakov
Institute of Computational Technologies, Siberian Branch of the Russian Academy of Sciences;
LLC BIOSOFT.RU
Russian Federation
Russian Federation
Kolpakov Fedor A. — PhD, Head of Laboratory of Bioinformatics, ICT SB RAS; Technical Director of BIOSOFT.RU, LLC
Novosibirsk
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Review
For citations:
Kolpakova A.F., Sharipov R.N., Volkova O.A., Kolpakov F.A. Role of air pollution by particulate matter in the pathogenesis of cardiovascular diseases. Prevention measures. Cardiovascular Therapy and Prevention. 2020;19(3):2421. (In Russ.) https://doi.org/10.15829/1728-8800-2020-2421
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