Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus
V. I. Simanenkov,
I. V. Maev,
O. N. Tkacheva,
S. A. Alekseenko,
D. N. Andreev,
D. S. Bordin,
T. D. Vlasov,
N. M. Vorobyeva,
V. Grinevich,
I. V. Gubonina,
M. Yu. Drobizhev,
N. S. Efremov,
А. E. Karateev,
Yu. V. Kotovskaya,
Iu. A. Kravchuk,
G. G. Krivoborodov,
E. V. Kulchavenya,
A. M. Lila,
M. V. Mayevskaya,
E. A. Poluektova,
T. V. Popkova,
O. A. Sablin,
O. I. Solovyeva,
A. N. Suvorov,
G. N. Tarasova,
D. I. Trukhan,
A. V. Fedotova https://doi.org/10.15829/1728-8800-2021-2758
Abstract
The purpose of the first multidisciplinary Consensus: to comprehensively analyze the pathophysiological, clinical, and pharmacotherapeutic aspects of the syndrome of increased epithelial permeability (SPEP) as one of the basic mechanisms of the development of human pathology.
The Consensus presents the structure of the three main levels of cytoprotection: preepithelial, epithelial and subepithelial, and the structure of intercellular tight contacts in epithelial tissues and endothelium is considered in detail. The clinical sections of the Consensus are devoted to the role of SPEP in diseases of the digestive system, cardio-cardio-vascular and other visceral systems. A separate section summarizes the materials illustrating the significant role of SPEP in mental disorders and diseases of the nervous system.
A separate chapter of the Consensus is devoted to cytoprotective therapy in SPEP. Cytoprotective effects of such proton pump inhibitor as rabeprazole, bismuth preparations and probiotics have been shown. Special attention is paid to the clinical and pharmacological specialties of the cytoprotector of rebamipide. Clinical the effectiveness of re-bamipide shown as in functional, so in organic lesions of the digestive system. Its anti-cancer preventive effects are of practical importance.
About the Authors
V. I. Simanenkov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
I. V. Maev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
O. N. Tkacheva
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
S. A. Alekseenko
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
D. N. Andreev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
D. S. Bordin
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
T. D. Vlasov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
N. M. Vorobyeva
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
V. Grinevich
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
I. V. Gubonina
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
M. Yu. Drobizhev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
N. S. Efremov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
А. E. Karateev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
Yu. V. Kotovskaya
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
Iu. A. Kravchuk
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
G. G. Krivoborodov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
E. V. Kulchavenya
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
A. M. Lila
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
M. V. Mayevskaya
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
E. A. Poluektova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
T. V. Popkova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
O. A. Sablin
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
O. I. Solovyeva
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
A. N. Suvorov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
G. N. Tarasova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
D. I. Trukhan
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation
Russian Federation
Moscow
A. V. Fedotova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Moscow
Review
For citations:
Simanenkov V.I., Maev I.V., Tkacheva O.N., Alekseenko S.A., Andreev D.N., Bordin D.S., Vlasov T.D., Vorobyeva N.M., Grinevich V., Gubonina I.V., Drobizhev M.Yu., Efremov N.S., Karateev А.E., Kotovskaya Yu.V., Kravchuk I.A., Krivoborodov G.G., Kulchavenya E.V., Lila A.M., Mayevskaya M.V., Poluektova E.A., Popkova T.V., Sablin O.A., Solovyeva O.I., Suvorov A.N., Tarasova G.N., Trukhan D.I., Fedotova A.V. Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus. Cardiovascular Therapy and Prevention. 2021;20(1):2758. (In Russ.) https://doi.org/10.15829/1728-8800-2021-2758
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