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Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus

https://doi.org/10.15829/1728-8800-2021-2758

Abstract

The purpose of the first multidisciplinary Consensus: to comprehensively analyze the pathophysiological, clinical, and pharmacotherapeutic aspects of the syndrome of increased epithelial permeability (SPEP) as one of the basic mechanisms of the development of human pathology.

The Consensus presents the structure of the three main levels of cytoprotection: preepithelial, epithelial and subepithelial, and the structure of intercellular tight contacts in epithelial tissues and endothelium is considered in detail. The clinical sections of the Consensus are devoted to the role of SPEP in diseases of the digestive system, cardio-cardio-vascular and other visceral systems. A separate section summarizes the materials illustrating the significant role of SPEP in mental disorders and diseases of the nervous system.

A separate chapter of the Consensus is devoted to cytoprotective therapy in SPEP. Cytoprotective effects of such proton pump inhibitor as rabeprazole, bismuth preparations and probiotics have been shown. Special attention is paid to the clinical and pharmacological specialties of the cytoprotector of rebamipide. Clinical the effectiveness of re-bamipide shown as in functional, so in organic lesions of the digestive system. Its anti-cancer preventive effects are of practical importance.

About the Authors

V. I. Simanenkov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



I. V. Maev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



O. N. Tkacheva
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



S. A. Alekseenko
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



D. N. Andreev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



D. S. Bordin
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



T. D. Vlasov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



N. M. Vorobyeva
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



V. Grinevich
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



I. V. Gubonina
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



M. Yu. Drobizhev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



N. S. Efremov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



А. E. Karateev
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



Yu. V. Kotovskaya
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



Iu. A. Kravchuk
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



G. G. Krivoborodov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



E. V. Kulchavenya
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



A. M. Lila
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



M. V. Mayevskaya
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



E. A. Poluektova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



T. V. Popkova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



O. A. Sablin
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



O. I. Solovyeva
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



A. N. Suvorov
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



G. N. Tarasova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



D. I. Trukhan
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM
Russian Federation

Moscow



A. V. Fedotova
National Medical Association for the Study of the Multimorbidity; Fund PROFMEDFORUM

Moscow



Review

For citations:


Simanenkov V.I., Maev I.V., Tkacheva O.N., Alekseenko S.A., Andreev D.N., Bordin D.S., Vlasov T.D., Vorobyeva N.M., Grinevich V., Gubonina I.V., Drobizhev M.Yu., Efremov N.S., Karateev А.E., Kotovskaya Yu.V., Kravchuk I.A., Krivoborodov G.G., Kulchavenya E.V., Lila A.M., Mayevskaya M.V., Poluektova E.A., Popkova T.V., Sablin O.A., Solovyeva O.I., Suvorov A.N., Tarasova G.N., Trukhan D.I., Fedotova A.V. Syndrome of increased epithelial permeability in clinical practice. Multidisciplinary national Consensus. Cardiovascular Therapy and Prevention. 2021;20(1):2758. (In Russ.) https://doi.org/10.15829/1728-8800-2021-2758

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)