Preview

Cardiovascular Therapy and Prevention

Advanced search

Comparative characteristics of risk factors as predictors of coronary heart disease in women during an epidemiological and clinical examination

https://doi.org/10.15829/1728-8800-2019-1-90-94

Abstract

Aim. To analyze main risk factors (RF) according to the epidemiological and clinical study and to determine the predictors of the development of coronary artery disease (CAD) in women.

Material and methods. The study included 200 women with CAD who were divided into 2 groups: I-epidemiological and II-clinical (99 and 101 patients respectively). For verification of CAD, patients were provided with a full range of epidemiological and clinical-instrumental studies.

Results. It was shown that relative risk (RR) mean values (1-2) were in BMI, abdominal obesity, arterial hypertension, hypertriglyceridemia (HTG) and HDL-hypocholesterolemia. Its higher values are for hypercholesterolemia (RR=1,2), atherogenic index (RR=1,4) and LDL-hypercholesterolemia (RR=1,5). As for additional RF, the RR for estradiol was 1,2. The highest RR was for progesterone, reaching 3,5 and for testosterone — 2,8.

Conclusion. We determined that if among the traditional RF there are no independent predictors of CAD, specialists in clinical practice can primarily use hormones (progesterone and testosterone).

About the Authors

F. N. Kasumova
A. Aliyev Azerbaijan State Advanced Training Institute for Doctors
Azerbaijan
Baku


N. A. Faradzheva
A. Aliyev Azerbaijan State Advanced Training Institute for Doctors
Azerbaijan
Baku


R. N. Mamedova
A. Aliyev Azerbaijan State Advanced Training Institute for Doctors
Azerbaijan
Baku


S. S. Sultanova
A. Aliyev Azerbaijan State Advanced Training Institute for Doctors
Azerbaijan
Baku


References

1. Shalnova SA, Oganov RG, Stag FG, Ford I. Coronary heart disease. Modern reality according to the world register CLARIFY. Kardiologiia. 2013;8:28-33. (In Russ.)

2. Popov DA. Risk factors for coronary heart disease. Russian Medical Journal. 2001;9(9). (In Russ.)

3. Oganov RG, Maslennikova GYa, Shalnova SA, Deev AD. Importance of controlling risk factors for the prevention of chronic non-infectious diseases. Prevention of Disease and Health Promotion. 2005;6:23-5. (In Russ.)

4. Petrov EE, Kazakov YuM, Chekalina NI. Some features of risk factors for coronary heart disease in women. Part 2. Bulletin of the problems of biology and medicine. 2014;1(1):23-30. (In Russ.)

5. Klimov AN, Lipovetsky BM. To be or not to be a myocardial infarction? Moscow, 2012, 41 p. (In Russ.)

6. Kiselev AR, Neufeld IV, Balashov SV. Factors of cardiovascular risk in postmenopausal women. Clinician. 2014;8(1):9-14. (In Russ.)

7. Levit RD, Reynolds HR, Hochman JS. Cardiovascular disease in young women: a population at risk. Cardiology in Review. 2011;19(2):60-5. doi:10.1097/CRD.0b013e31820987b5.

8. Maas AH, Appelman YE. Gender differences in coronary heart disease. Neth Heart J. 2010;18(12):598-603.

9. Yureneva SV, Mychka VB, Il’ina LM, Tolstov SN. Features of risk factors for cardiovascular disease in women and the role of sex hormones. Cardiovascular Therapy and Prevention. 2011;10(4):128-35. (In Russ.)

10. Ratiani L, Parkosadze G, Cheishvili M, et al. Role of estrogens in pathogenesis of agerelated disease in women of menopausal age. Georgian Med News. 2012;(203):6-11.

11. Jouyandeh Z, Nayebzadeh F, Qorbani M, Asadi M. Metabolic syndrome and menopause. J Diabetes Metab Disord. 2013;12(1):1. doi:10.1186/2251-6581-12-1.

12. Wellons M, Ouyang P, Schreiner PJ, et al. Early menopause predicts future coronary heart disease and stroke: the Multiethnic Study of Atherosclerosis. Menopause 2012;19:1081-7. doi:10.1097/gme.0b013e3182517bd0.

13. Ciambrone G, Kaski JC. The importance of gender differences in the diagnosis and management of cardiovascular disease. Current Pharmaceutical Design. 2011;17(11):1079-81.

14. Tsygankova OV, Bondareva ZG, Fedorova EL, et al. Female face of coronary heart disease: the metabolic and psychological status of patients of different ages with acute myocardial infarction. Fundamental Research. 2010;11:133-7. (In Russ.)

15. Gurevich MA. Diagnosis and treatment of coronary heart disease in women. Diseases of the heart and blood vessels. 2007;3:38-46. (In Russ.)

16. Britton KA, Massaro JM, Murabito JM, et al. Body fat distribution, incident cardiovascular disease, cancer, and all-cause mortality. JACC. 2013;62(10):921-5.

17. Yureneva SV, Ilina LM, Mychka VB. Sex hormones and cardiovascular risk: critical periods in the life of women. Effective pharmacotherapy. Cardiology and Angiology. 2011;2:32-7. (In Russ.)

18. Zhao D, Guallar E, Ouyang P, et al. Endogenous sex hormones and incident cardiovascular disease in post-menopausal women. JAСC. 2018;71(22):2555-66. doi:10.1016/j.jacc.2018.01.083.

19. Yureneva SV, Ilina LM. Predictors of cardio-vascular risk in women: a role for sexual hormones and lifestyle. Effective Pharmacotherapy (Endocrinology). 2013;6:14- 24. (In Russ.)


Review

For citations:


Kasumova F.N., Faradzheva N.A., Mamedova R.N., Sultanova S.S. Comparative characteristics of risk factors as predictors of coronary heart disease in women during an epidemiological and clinical examination. Cardiovascular Therapy and Prevention. 2019;18(1):90-94. (In Russ.) https://doi.org/10.15829/1728-8800-2019-1-90-94

Views: 977


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 License.


ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)