Noliprel and endothelial dysfunction correction in metabolic syndrome patients
Abstract
Aim. To study endothelial functional status dynamics in metabolic syndrome (MS) patients receiving Noliprel® therapy.
Material and methods. In 39 patients with diagnosed MS, endothelial functional status (reactive hyperemia and nitroglycerin tests), microcirculation (MC) and 24-hour blood pressure monitoring (BPM) parameters were assessed during 6-month Noliprel ® therapy.
Results. After 6 month of Noliprel® therapy, systolic and diastolic BP levels significantly decreased (р<0.01 and р<0.05, respectively), 24-hour BPM parameters improved. Endothelium-dependent vasodilatation increased, that was a symptom of endothelial function improvement. MC parameters also improved, initially reduced prostacyclin level increased (р<0.01), and initially increased thromboxane concentration decreased (р<0.01). Microalbuminuria and proteinuria levels significantly reduced (р<0.01).
Conclusion. Noliprel® improved endothelial function in MS patients. Endothelial dysfunction correction changed vascular reactivity to vasoconstrictors, regardless of vessel size, and therefore, improved hemodynamic and hemostatic parameters.
About the Authors
V. V. Trusov
Izhevsk State Medical Academy, Izhevsk
Russian Federation
Russian Federation
M. A. Filimonov
Izhevsk State Medical Academy, Izhevsk
Russian Federation
Russian Federation
K. V. Aksenov
Izhevsk State Medical Academy, Izhevsk
Russian Federation
Russian Federation
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Review
For citations:
Trusov V.V., Filimonov M.A., Aksenov K.V. Noliprel and endothelial dysfunction correction in metabolic syndrome patients. Cardiovascular Therapy and Prevention. 2005;4(6, ч.I):62-66. (In Russ.)
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