Continuous positive airway pressure therapy and carbohydrate and lipid metabolism in patients with Z syndrome
Abstract
Aim. To examine continuous positive airway pressure (CPAP) therapy effects on carbohydrate and lipid metabolism in patients with metabolic syndrome (MS) and obstructive sleep apnea syndrome (OSAS).
Material and methods. The study involved 62 MS patients: 20 females and 42 males, aged 39-66 years (mean age 52.4±7.6 years). Control group included 15 patients without OSAS, another 47 had OSAS of varying severity (main group). CPAP therapy was administered to 11 OSAS patients for 12 weeks. At baseline and 12 weeks later, height, body weight (BW), waist and hips circumference (WC, HC) were measured, with body mass index calculation (BMI); levels of total cholesterol (TCH), high-density lipoprotein (HDL) CH, triglycerides (TG), glucose, leptin, resistin, adiponectin were assessed; glucose tolerance test and 24-hour blood pressure (BP) monitoring were performed.
Results. BW, BMI, WC, WC/HC, TCH decrease wasn’t statistically significant. HDL CH level increased from 0.99±0.2 to 1.12±0.1 mmol/l (р<0.05). TG concentration decreased from 4.18±3.3 to 2.31±1.2 mmol/l (р<0.05). Fasting glucose level fell from 5.8±0.8 to 5.3±0.3 mmol/l (р<0.05), and after glucose load test – from 8.3±1.8 to 6.5±1.9 mmol/l (р<0.05). Adipocytokine levels significantly improved: leptin level decreased from 15.14±4.6 to 11.17±5.2 ng/ml (р<0.05); resistin concentration – from 3.02±0.87 to 2.5±0.51 ng/ml (p<0.05), and adiponectin level increased form 2.44±0.6 to 3.34±0.9 ng/ml (p<0.05).
Conclusion. Effective CPAP therapy significantly improved metabolic parameters in patients with MS and OSAS.
About the Authors
R. A. Galyavi
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development, Moscow
Russian Federation
Russian Federation
A. Yu. Litvin
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development, Moscow
Russian Federation
Russian Federation
I. E. Chazova
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, Russian Federal Agency of Health and Social Development, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Galyavi R.A., Litvin A.Yu., Chazova I.E. Continuous positive airway pressure therapy and carbohydrate and lipid metabolism in patients with Z syndrome. Cardiovascular Therapy and Prevention. 2005;4(6, ч.I):67-75. (In Russ.)
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