DYNAMICS OF LEFT VENTRICULAR PARAMETERS IN THE LONG-TERM TREATMENT OF RENAL PARENCHYMATOUS ARTERIAL HYPERTENSION
https://doi.org/10.15829/1728-8800-2013-1-10-16
Abstract
Aim. To investigate the dynamics of left ventricular (LV) parameters during the long-term treatment of renal parenchymatous arterial hypertension (RPAH) in patients with primary chronic glomerulonephritis and preserved renal function.
Material and methods. The long-term follow-up included 136 RPAH patients with preserved renal function. Clinical assessment of blood pressure (BP) levels, 24-hour BP monitoring, and Doppler echocardiography (EchoCG) were performed at baseline and during the complex antihypertensive therapy (AHT) and pathogenetic therapy of RPAH patients. The treatment-related dynamics of LV structure and function was evaluated.
Results. The long-term complex treatment of RPAH patients resulted in significantly reduced clinical BP levels, improved 24-hour BPM parameters, LV hypertrophy (LVH) regression, and improved diastolic and systolic LV function.
Conclusion. The long-term complex AHT, in combination with pathogenetic therapy, resulted not only in reduced BP levels and improved circadian BP profile, but also in improved diastolic and systolic LV function and LVH regression among RPAH patients with preserved renal function.
About the Authors
N. Yu. Borovkova
Nizhny Novgorod State Medical Academy
Russian Federation
Russian Federation
N. N. Borovkov
Nizhny Novgorod State Medical Academy
Russian Federation
tel.: (831) 438–93–27
Russian Federation
tel.: (831) 438–93–27
Yu. A. Khor’kina
Nizhny Novgorod State Medical Academy
Russian Federation
Russian Federation
E. O. Obukhova
Nizhny Novgorod State Medical Academy
Russian Federation
Russian Federation
A. I. Arshinova
N.A. Semashko Nizhny Novgorod Regional Clinical Hospital, Nizhny Novgorod
Russian Federation
Russian Federation
References
1. Diagnostics and treatment of arterial hypertension. Russian recommendations (the fourth revision). System hypertensia 2010; 3: 5–26. Russian (Диагностика и лечение артериальной гипертензии. Российские рекомендации (четвертый пересмотр). Системные гипертензии 2010; 3: 5–26).
2. Devereux R, Facc M. Left ventricular geomertry, pathophysiology and prognosis. JACC 1995; 25: 885–7.
3. Krumholz H, Larson M, Levy D. Prognosis of left ventricular geometric patterns in Framingham heart study. JACC 1995; 25: 879–84.
4. Shlyakhto EV, Konradi AO. Remodelingof heart at aessential hypertension. Heart 2002; 1 (5): 232–4. Russian (Шляхто Е.В., Конради А.О. Ремоделирование сердца при гипертонической болезни. Сердце 2002; 1 (5): 232–4).
5. Kotovskaja YuV, Kobalava ZhD. Blood pressure monitoring in clinical practice: whether we overestimate its value? Arterial hypertension 2004; 10 (1): 5–12. Russian (Котовская Ю.В., Кобалава Ж. Д. Суточное мониторирование артериального давления в клинической практике: не переоцениваем ли мы его значение? Артериальная гипертензия 2004; 10 (1): 5–12).
6. Tomilina NA, Volgina GV, Bikbov BT, et al. A problem of cardiovascular diseases inend-stage renal disease. Nephrology and Dialysis 2003; 5 (1): 15–24. Russian (Томилина Н. А., Волгина Г.В., Бикбов Б. Т. и др. Проблема сердечно-сосудистых заболеваний при хронической почечной недостаточности. Нефрология и диализ 2003; 5 (1): 15–24).
7. Foley R, Parfrey P, Sarnak M. Epydemiology of cardiovascular disease in chronic renal failure. Am J Kidney Dis 1998; 32: 12–9.
8. Ilyin AP. A cardiovascular continuum at patients with end-stage renal diseaseon a program hemodialysis. Warminsufficiency 2003; 3: 31–4. Russian (Ильин А.П. Сердечно-сосудистый континуум у больных хро- нической почечной недостаточностью находящихся на программном гемодиализе. Сердечная недостаточность 2003; 3: 31–4).
9. Volgina GV. A hypertrophy of the left ventricle of heart at patients with dodializnyend-stage renal disease. Cardiovascular Therapy and Prevention 2002; 1 (4): 68–75. Russian (Волгина Г.В. Гипертрофия левого желудочка сердца у больных с додиализной хронической почечной недостаточностью. Кардиоваскулярная терапия и профилактика 2002; 1 (4): 68–75).
10. ESH — ESC Guidelines Committee. ESH — ESC guidelines for the management of arterial hypertension. J Hypertens 2003; 21: 1011–53.
11. Ryabov SI. Nephrology. SPb: Speclit 2000; 672 p. Russian (Рябов С.И. Нефрология. СПб: Спецлит 2000; 672 с).
12. Hebert LA, Kusek JW, Greene T. et al. Modification of Diet in Renal Disease Study Group. Effects of blood pressure control on progressive renal disease in blacks and whites. J Hypertens 1997; 30: 428–35.
13. Rogoza AN. Blood pressure monitoring. Heart 2002; 1 (5): 240–2. Russian (Рогоза А.Н. Суточное мониторирование артериального давления. Сердце 2002; 1 (5): 240–2).
14. Teichholtz L, Kreulen T, Herman M. Problems in echocardiographic — angiographic correlations in the presence or absence asynergy. Am J Cardiol 1976; 37: 7–11.
15. Ovchinnikov AG, Ageev FT, Mareev VYu. Methodical aspects of application of aechocardiographic in diagnostics of diastolic dysfunction a levt ventricular. Warminsufficiency 2000; 1 (2):12–20. Russian (Овчинников А. Г., Агеев Ф.Т., Мареев В.Ю. Методические аспекты применения допплеэхокардиографии в диагностике диастолической дисфункции левого желудочка. Сердечная недостаточность 2000; 1 (2): 12–20).
Review
For citations:
Borovkova N.Yu., Borovkov N.N., Khor’kina Yu.A., Obukhova E.O., Arshinova A.I. DYNAMICS OF LEFT VENTRICULAR PARAMETERS IN THE LONG-TERM TREATMENT OF RENAL PARENCHYMATOUS ARTERIAL HYPERTENSION. Cardiovascular Therapy and Prevention. 2013;12(1):10-16. (In Russ.) https://doi.org/10.15829/1728-8800-2013-1-10-16
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