Main results of the Russian trial «ALTAIR»
Abstract
The results of the multi-center, open, titrating trial of rilmenidine «ALTAIR» (ALbarel: effectiveness and Tolerability in ArterIal hypeRtension) are demonstrated. Aim. To assess antihypertensive effectiveness and safety of rilmenidine as monotherapy and in combination with amlodipine in out-patients with mild to moderate arterial hypertension (AH), to investigate its effects on quality of life and treatment compliance. Material and methods. The study involved 677 patients: 610 participants (90.4%) completely fulfilled the protocol, and another 67 (9.6%) dropped out. Therapy lasted for 16 weeks. Clinical visits were performed at Week 4, 8, 12 and 16 of the treatment. Results. Rilmenidine (1-2 mg/d) therapy in Stage I-II AH was associated with BP target level achievement in 46.6% of the cases, with good therapy tolerability. Adverse events were registered in 11.9% of the participants, but treatment discontinuation and study termination was necessary in 4.4% of the subjects only. Combination of rilmenidine and amlodipine (2.5-5 mg/d) resulted in responder percentage increase to 87.5%, with simultaneous increase in adverse event rates, though. Conclusion. ALTAIR trial results demonstrated high effectiveness and good tolerability of rilmenidine treatment, as monotherapy or in combination with amlodipine.
About the Authors
E. V. Shlyakhto
V.A. Almazov Research Institute of Cardiology, Russian Federal Agency of Health and Social Development. St. Petersburg
Russian Federation
Russian Federation
A. O. Conrady
V.A. Almazov Research Institute of Cardiology, Russian Federal Agency of Health and Social Development. St. Petersburg
Russian Federation
Russian Federation
Yu. V. Sviryaev
V.A. Almazov Research Institute of Cardiology, Russian Federal Agency of Health and Social Development. St. Petersburg
Russian Federation
Russian Federation
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Review
For citations:
Shlyakhto E.V., Conrady A.O., Sviryaev Yu.V. Main results of the Russian trial «ALTAIR». Cardiovascular Therapy and Prevention. 2006;5(1):21-30. (In Russ.)
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