COMBINED ACTION ANTIHYPERTENSIVE AGENT URAPIDIL: EFFECTIVENESS AND SAFETY IN CLINICAL PRACTICE
https://doi.org/10.15829/1728-8800-2014-1-57-63
- Р Р‡.МессенРТвЂВВВВВВВВжер
- РћРТвЂВВВВВВВВнокласснРСвЂВВВВВВВВРєРСвЂВВВВВВВВ
- LiveJournal
- Telegram
- ВКонтакте
- РЎРєРѕРїРСвЂВВВВВВВВровать ссылку
Full Text:
Abstract
The paper reviews the clinical practice potential of a combined action antihypertensive medication urapidil for the treatment of patients with acute elevation of blood pressure (BP) and confirms urapidil effectiveness and good tolerability. Urapidil action mechanisms, pharmacodynamics, and pharmacokinetics are discussed, together with the results of the key clinical trials which have demonstrated antihypertensive effectiveness and safety of this agent. Additional beneficial effects of urapidil, such as reduction of the increased pulmonary artery BP and improvement of bronchial conductivity, are also described.
About the Authors
N. I. Gaponova
A.I. Evdokimov Moscow State Medico-Stomatological University
Russian Federation
Russian Federation
V. R. Abdrakhmanov
A.I. Evdokimov Moscow State Medico-Stomatological University
Russian Federation
Russian Federation
V. A. Kadyshev
A.S. Puchkov Emergency Medical Care Station. Moscow, Russia
Russian Federation
Russian Federation
A. Yu. Sokolov
A.S. Puchkov Emergency Medical Care Station. Moscow, Russia
Russian Federation
Russian Federation
References
1. Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005; 365: 217-23.
2. Shal’nova SA, Kukushkin SK, Manoshkina EM, et al. Arterial hypertension and adherence to therapy. Vrach 2009; 12: 39-2. Russian (Shal'nova S. A., Kukushkin S. K., Manoshkina E. M. i dr. Arterial'naya gipertenziya i priverzhennost' terapii. Vrach 2009; 12: 39-2).
3. Hypertensive crises. Edited by Tereshhenko SN, Plavunova NF. M., MEDpressinform 2013; 207 r. Russian (Gipertonicheskie krizy. Pod red. Tereshchenko S. N., Plavunova N. F., M., MEDpress-inform 2013; 207 s).
4. Leonetti G, Terzoli L, Zanchetti A. Systemic haemodynamic and humoral changes during urapidil treatment in hypertensive patients. J Hypertens 1988; 6 (2): 25-9.
5. Langtry HD, Mammen GJ, Sorkin EM. Urapidil: a review of its pharmacodynamic and pharmacokinetic properties and therapeutic potential in the treatment of hypertension. Drugs 1989; 38: 900-40.
6. Spah F, Kottmann R, Grosser KD, et al. Effects of urapidil in patients with mild pulmonary vascular hypertension. Drugs 1990; 40 (4): 69-70.
7. Zadionchenko VS, Pogonchenkova IV, Adasheva TV. Arterial hypertension in chronic obstructive pulmonary disease. M. 2005; 134 r. Russian (Zadionchenko V. S., Pogonchenkova I. V., Adasheva T. V. Arterial'naya gipertoniya pri khronicheskoi obstruktivnoi bolezni legkikh. M. 2005; 134 c).
8. Ramage AG. The mechanism of the sympathoinhibitory action of urapidil: role of 5-HT1A receptors. Br J Pharmacol 1991; 102: 998-1002.
9. Gillis RA, Dretchen KL, Namath I, et al. Hypotensive effect of urapidil: CNS site and relative contribution. J Cardiovasc Pharmacol 1987; 9: 103-9.
10. Medicines Register of Russia RLS. Encyclopedia of medicines. 18th edition. M. RLS-MEDIA, 2009; 1440 r. Russian (Registr lekarstvennykh sredstv Rossii RLS. Entsiklopediya lekarstv. 18-i vyp. M. RLS-MEDIA 2009; 1440 c).
11. Semenova EV, Golikov AP, Ryabinin VA, Luk’yanov MM. Treatment of hypertensive crisis with an integrated dynamic control. TOP Medicina 1998; 2: 6-8. Russian (Semenova E. V., Golikov A. P., Ryabinin V. A., Luk'yanov M. M. Lechenie gipertonicheskikh krizov s ispol'zovaniem kompleksnogo dinamicheskogo kontrolya. TOP Meditsina 1998; 2: 6-8).
12. Arutyunov GP, Oganezova LG. Relief of the complicated hypertensive crisis in the practice of the therapist: a place of urapidil and results of research. Racional’naja farmakoterapija v kardiologii 2011; 7 (5): 549-54. Russian (Arutyunov G. P., Oganezova L. G. Kupirovanie oslozhnennogo gipertonicheskogo kriza v praktike terapevta: mesto urapidila i rezul'taty issledovaniya. Ratsional'naya farmakoterapiya v kardiologii 2011; 7 (5): 549-54).
13. Yao DK, Jia SQ, Wang L, et al. Therapeutic effect of urapidil on myocardial perfusion in patients with ST-elevation acute coronary syndrome. Eur J Intern Med 2009; 20 (2): 152-7.
14. Castelhy PA, Lear S, Lear E, et al. Intrapulmonary shunting during induced hypotension. Anesthesia and Analgesia 1982; 61: 231-5.
15. Sivak ED, Starr NJ, Grave JW, et al. Extra vascular lung water values in patients undergoing coronary artery bypass surgery. Critic Care Med 1982; 10: 593-6.
16. Mollhoff T, Rosiers P, van Aken H. Urapidil, sodium nitroprusside and nitroglycerin: effects on haemodiynamics, venous admixture and arterial oxygenation after coronary artery bypass grafting. Drugs 1990; 40 (4): 73-6.
17. Wallard R, Karp RB, Reves JG, et al. Pathogenesis of paroxysmal hypertension developing during and after coronary bypass surgery. A study of hemodynamic and humoral factors. Am J Cardiol 1980; 46: 559-65.
18. Flaherty JT, Magee PA, Gardner TL, et al. Comparison of intravenous nitroglycerin and sodium nitroprusside for treatment of acute hypertenston developing after coronary artery bypass surgery. Circulation 1982; 65: 1072-7.
19. Adnot S, Radermacher P, Andrivet P, et al. Effects of sodium nitroprusside and urapidill on gas exchange and ventilation: perfusion ratios in patients with congestive heart failure. Drugs 1990; 40 (4): 65-6.
20. Cazzola M, Spinazzi A, Santangelo G, et al. Acute effects of urapidil on airway response in hypertensive patients with chronic obstructive pulmonary disease. Drugs 1990; 40 (4): 71-2.
21. Diagnosis and treatment of arterial hypertension. Russian recommendations (third revision). Cardiovascular Therapy and Prevention 2008; 7 (6), appendix 2: 32. Russian (Diagnostika i lechenie arterial'noi gipertenzii. Rossiiskie rekomendatsii (tretii peresmotr). Kardiovaskulyarnaya terapiya i profilaktika 2008; 7 (6), prilozhenie 2: 32).
22. Jorgensen HS, Nakayama H, Raaschou HO, Olsen TS. Effect of blood pressure and diabetes on stroke in progression. Lancet 1994; 344:156-9.
23. Willmot M, Leonardi-Bee J, Bath PM. High blood pressure in acute stroke and subsequent outcome: a systematic review. Hypertension 2004; 43:18-24.
24. Robinson TG, Waddington A, Ward-Close STN, Potter JF. The predictive role of 24-hour compared to casual blood pressure levels on outcome following acute stroke. Cerebrovasc Dis 1997; 7:264-72.
25. Robinson TG, Dawson SL, Ahmed U, Manktelow B, Fotherby MD, Potter JF. Twentyfour hour systolic blood pressure predicts long-term mortality following acute stroke. J Hypertens 2001; 19:2127-34.
26. European Stroke Organisation (ESO) Executive Committee and the ESO Writing Committee. Guidelines for Management of Ischaemic Stroke and Transient Ischaemic Attack 2008. Cerebrovasc Dis 2008; 25: 457-507.
27. Arima H, Anderson CS, Wang JG, et al. Intensive Blood Pressure Reduction in Acute Cerebral Haemorrhage Trial Investigators. Lower treatment blood pressure is associated with greatest reduction in hematoma growth after acute intracerebral hemorrhage. Hypertension 2010; 56 (5): 852-8.
28. Grossman E, Hironi AN, Messerli FH. Comparative tolerability profile of hypertensive crisis treatments. Drug Saf 1998; 19: 99-122.
29. Migneco A, Ojetti V, De Lorenzo A, et al. Hypertinsive crises: diagnosis and management in the emergency room. Eur Rev Med Pharmarcol Sciences 2004; 8: 143-52.
30. Morrell DF. Quality controlled hypotension. Medicina neotlozhnyh sostojanij 2007; 3: 127-34. Russian (Morrell DF. Kachestvennaya upravlyaemaya gipertenziya. Meditsina neotlozhnykh sostoyanii 2007; 3: 127-34).
31. Hirschl MM, Seidler D, Mullner M, et al. Efficacy of different antihypertensive drugs in the emergency department. Hypertens 1996; 24: 1684-9.
32. Alijotas-Reig J, Bove-Farre I, De Cabo-Frances F, et al. Effectiveness and safety of prehospital urapidil for hypertensive emergencies. Am J Emerg Med 2001; 19: 130-3.
33. Ruksin VV, Grishin OV, Jashhenkova SV. New features of the intensive care in the prehospital. Skoraja medicinskaja pomoshh’ 2011; 2:9-14. Russian (Ruksin V. V., Grishin O. V. Yashchenkova S. V. Novye vozmozhnosti intensivnoi terapii na dogospital'nom etape. Skoraya meditsinskaya pomoshch' 2011; 2: 9-14).
34. Dolley M, Goa KL. Urapidil. A reappraisal of its use in the management of hypertension. Drugs 1998; 56 (5): 529-55.
35. Beller KD, Boer R, Sanders KH, et al. Blockade of
Review
For citations:
Gaponova N.I., Abdrakhmanov V.R., Kadyshev V.A., Sokolov A.Yu. COMBINED ACTION ANTIHYPERTENSIVE AGENT URAPIDIL: EFFECTIVENESS AND SAFETY IN CLINICAL PRACTICE. Cardiovascular Therapy and Prevention. 2014;13(1):57-63. (In Russ.) https://doi.org/10.15829/1728-8800-2014-1-57-63
Views:
1485
ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)
ISSN 2619-0125 (Online)
Email this article 
