Fixed-dose combination of perindopril and indapamide: perspectives in hypertensive patients with inadequately controlled blood pressure
Abstract
Combined ACE inhibitor / diuretic therapy is one of the rational antihypertensive combinations for treating arterial hypertension (AH) patients. In a pharmaco-epidemiological, multicenter, open prospective study STRATEGY (Comparative program aSsessing noliprel effecTiveness in hypeRtensive pATiEnts with inadequatelY controlled blood pressure), it is planned to study clinical effectiveness and tolerability of perindopril / indapamide combination in more than 2000 patients with mild to moderate AH, in realworld clinical settings, during 4 months. The aim of the study is to compare rates of blood pressure (BP) reduction during combined perindopril / indapamide (Noliprel® or Noliprel® forte) therapy in the following clinical situations: initial antihypertensive therapy in newly diagnosed AH patients; continuous AH therapy in patients with BP above target levels, or with adverse effects of other agents; adding the combination to baseline therapy, in order to enhance antihypertensive effect.
About the Authors
I. E. Chazova
Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, Moscow
Russian Federation
Russian Federation
T. V. Martynyuk
Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development, Moscow
Russian Federation
Russian Federation
References
1. Профилактика, диагностика и лечение артериальной гипертонии. Российские рекомендации (второй пересмотр). Москва 2004.
2. Чазова И.Е. Комбинированная терапия артериальной гипертензии. Cons med 2001; Приложение (артериальная гипертензия): 22-6.
3. Townsend R, Holland O. Improved hypertension management and control. Arch Intern Med 1990; 150: 1175-83.
4. Chalmers J, Castaigne A, Morgan T, et al. Long-term efficacy of a new fixed very low dose angiotensin-converting enzyme inhibitor/diuretic combination as first line therapy in the elderly hypertensive patients. Am J Hypertens 2000; 18: 327-37.
5. Галеева З.М., Галявич А.С. Влияние фиксированной низкодозовой комбинации гипотензивных препаратов на клинико-биохимические характеристики больных артериальной гипертензией. Артер гиперт 2003; 9(6): 221-4.
6. Mallion J, Chastang C, Unger P. Efficacy and safety of a fixed very low dose perindopril/ indapamide combination in essential hypertension: a randomized controlled study. Clin Exp Hypertens 2000; 22: 23-32.
7. Levy BI, Ambrusio G, Pries AR, et al. Microcirculation in hypertension: a new target for treatment? Circulation 2001; 104: 735-40.
8. Mogensen CE, Viberti G, Halimi S. Effect of low-dose perindopril/ indapamide on albuminuria in diabetes. Hypertension 2003 ; 41: 1063-71.
9. ADVANCE Management Committee. Study rationale and design of ADVANCE action in diabetes and vascular disease: Preterax and Diamicron MR controlled evaluation. Diabetologia 2001; 44: 1118-2.
Review
For citations:
Chazova I.E., Martynyuk T.V. Fixed-dose combination of perindopril and indapamide: perspectives in hypertensive patients with inadequately controlled blood pressure. Cardiovascular Therapy and Prevention. 2007;6(1):18-22. (In Russ.)
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