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Cardiovascular Therapy and Prevention

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Clinical pharmacogenetics of angiotensin II receptor blockers: new perspectives of pharmacotherapy individualization

Abstract

The review focuses on clinical practice perspectives for angiotensin II receptor blockers (ARB). The authors discuss the results of the trials on biotransformation genes (CYP2C9) polymorphism and renin-angiotensin-aldosterone system influence on ARB pharmacokinetics and pharmacodynamics. Pharmacogenetic studies have been performed not only in healthy volunteers, but also in patients with arterial hypertension or chronic heart failure.

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Sychev D.A., Anikin G.S., Belolipetskaya V.G., Ignatyev I.B., Kukes V.G. Clinical pharmacogenetics of angiotensin II receptor blockers: new perspectives of pharmacotherapy individualization. Cardiovascular Therapy and Prevention. 2006;5(2):100-105. (In Russ.)

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)