Coronary heart disease treatment: old principles and new horizons
Abstract
Basing on literature data, the authors demonstrate the link between heart rate (HR) and mortality in coronary heart disease (CHD) and arterial hypertension. HR reduction strategy as an important therapeutic target in CHD management is proposed. Ant-ischemic and antianginal mechanisms of a novel agent, ivabradine, selectively reducing HR due to sinus node f-channel ion current inhibition, are discussed. Clinical evidence of ivabradine effectiveness in stable angina, comparing to other modern antianginal medications, is presented. Potential benefits of ivabradine therapy in HR reduction-requiring clinical situations are discussed.
About the Authors
Yu. A. Vasyuk
Moscow State Medico-Stomatological University, Moscow
Russian Federation
Russian Federation
E. L. Shkol’nik
Moscow State Medico-Stomatological University, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Vasyuk Yu.A., Shkol’nik E.L. Coronary heart disease treatment: old principles and new horizons. Cardiovascular Therapy and Prevention. 2007;6(1):92-98. (In Russ.)
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