Influence of betahistine dihydrochloride and antihypertensive medication combination on neurological status and quality of life in patients with stable arterial hypertension and vertigo

Aim. To assess the effects of combined lisinopril and betahistine dihydrochloride (Betaserc®) therapy on quality of life (QoL) and neurological status in patients with stable, mild to moderate arterial hypertension (AH) and vertigo. Material and methods. This randomized, cross-over, placebo-controlled study included 67 patients with stable, mild to moderate AH, Stage I-II, Risk 2-3 (20% of males, 80% of females). After two-week medication-free period, all participants were randomized into lisinopril or lisinopril plus Betaserc® groups. After one-month therapy and two-week washout period, patients moved to another group. Twenty-four-hour blood pressure monitoring (BPM), and QoL assessment were performed before and after each therapy course, neurological status was assessed after first course only Results. Both therapy schemes had similar antihypertensive effects on 24-hour BPM main parameters. Lisinopril monotherapy and combined treatment were both associated with neurological status improvement. But only in patients taking lisinopril and Betaserc®, the results of most remote point test increased significantly. During lisinopril therapy, QoL parameters improved for scales on physical health self-esteem, workability, and positive psychological health self-esteem. Combined therapy was associated with improvement in scales on physical health self-esteem, workability, positive and negative psychological health self-esteem, social contact openness. Conclusion. Lisinopril monotherapy and combined Betaserc® and lisinopril therapy had similar antihypertensive effect. Сombined therapy improved QoL better than lisinopril monotherapy. In Stable AH patients, vertigo was typically caused by chronic bilateral pathology of vestibular system.

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