Chronic bacterial and viral infection exacerbation as a possible risk factor for acute coronary syndrome development in coronary heart disease patients
Abstract
Aim. To identify new, non-traditional risk and precipitating factors, that, combined with chronic chlamydial and viral infection, could provoke coronary atherosclerosis destabilization and acute coronary crise development. Material and methods. In total, 66 coronary heart disease (CHD) patients were examined, who had stable effort angina or acute coronary syndrome (ACS), and were sero-positive for Chl. Pneumoniae, HSV-I, CMV and EBV viruses. Control group included 20 sero-negative CHD patients. Serological status was determined by ELISA immuno-enzyme method. Results. Triad of plasma markers: C-reactive protein (CRP), МВ-creatine kinase, and lipid hydroperoxide activity – was identified, that can be used, together with serological status data, for more effective ACS diagnostics. Conclusion. Recurrent infection might play a role as one of the triggers for chronic CHD transformation into its acute or instable forms.
About the Authors
T. G. Kvantaliani
Academician M.D. Tsinamdzgvirishvili Institute of Cardiology;
Georgean Society of Cardiology. Tbilisi
Georgia
Georgia
V. B. Chumburidze
Academician M.D. Tsinamdzgvirishvili Institute of Cardiology;
Georgean Society of Cardiology. Tbilisi
Georgia
Georgia
P. A. Tsiklauri
Academician M.D. Tsinamdzgvirishvili Institute of Cardiology;
Georgean Society of Cardiology. Tbilisi
Georgia
Georgia
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Review
For citations:
Kvantaliani T.G., Chumburidze V.B., Tsiklauri P.A. Chronic bacterial and viral infection exacerbation as a possible risk factor for acute coronary syndrome development in coronary heart disease patients. Cardiovascular Therapy and Prevention. 2006;5(5):36-40. (In Russ.)
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