Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients
Abstract
Aim. To study arteriolar blood flow velocity and salt consumption in patients with Type 2 diabetes mellitus (DM-2) and arterial hypertension (AH); to clarify the causes and pathogenetic mechanisms of the latter.
Material and methods. In total, 258 patients with DM-2 and AH were examined (mean age 54+1,16 years, disease duration 9,8+0,91 years). The control group (CG) included 110 age-matched healthy people. Taste sensitivity to salt (TSS), 24-hour urinary sodium excretion, and microcirculatory Doppler ultrasound were performed.
Results. In patients with DM-2 and AH, decreased TSS resulted in involuntary increase of salt intake with food, which was confirmed by increased urinary sodium excretion. Arteriolar blood flow was significantly decreased in DM-2 participants, which indirectly pointed to arteriolar vasodilatation in AH.
Conclusion. Volume-dependent mechanism (hypervolemia) plays a leading role in AH genesis among DM-2 patients. This should be taken into consideration while planning treatment and prevention strategies in individuals with DM-2 and AH.
About the Authors
V. S. Volkov
Tver State Medical Academy. Tver
Russian Federation
Russian Federation
E. V. E.V. Rudenko
Tver State Medical Academy. Tver
Russian Federation
Russian Federation
S. A. Rokkina
Tver State Medical Academy. Tver
Russian Federation
Russian Federation
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Review
For citations:
Volkov V.S., E.V. Rudenko E.V., Rokkina S.A. Pathogenesis, treatment, and prevention of arterial hypertension in Type 2 diabetes mellitus patients. Cardiovascular Therapy and Prevention. 2008;7(3):14-17. (In Russ.)
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