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Еprosartan therapy effectiveness in arterial hypertension patients after stroke or transient ischemic attack

Abstract

Aim. To study effectiveness, safety, and dynamics of cognitive function in eprosartan therapy among arterial hypertension (AH) patients after stroke (S) or transient ischemic attack (TIA), comparing to standard antihypertensive therapy. Material and methods. The study included 60 AH patients, who underwent S or TIA. All participants wee randomized to two equal groups. Mean age in Group I was 62,2±7,8 years, in Group II – 59,8±6,7 years; AH duration - 9,5±3,5 and 9,8±3,2 years, respectively. For 3 months, Group I received eprosartan (600 mg/d), as monotherapy or combined with hydrochlorthiazide, if target blood pressure (BP) level was not achieved. Group II received standard antihypertensive therapy. At 4 visits, BP, heart rate, body mass index were measured; medication tolerability were assessed. At the baseline and at the end of the study, electrocardiography, echocardiography, 24-hour BP monitoring (BPM), psychological testing with Beck and MMSE questionnaires were performed. Results. In 2 patients (6,7%) from control Group II, recurrent TIA episodes were registered. In both groups, a significant positive dynamics of all manually measured BP parameters was observed. At the end of the study, BP positive dynamics was more manifested in eprosartan group. Moreover, in Group I, depression and cognitive dysfunction levels substantially decreased. Conclusion. Eprosartan is an effective antihypertensive agent for AH treatment, with cerebroprotective effects in S and TIA patients, that could be used as monotherapy or in combination with a diuretic.

About the Authors

Yu. M. Pozdnyakov
Moscow Regional Cardiology Center. Zhukovsky
Russian Federation


A. M. Urinsky
Moscow Regional Cardiology Center. Zhukovsky
Russian Federation


R. L. Kuznetsov
Moscow Regional Cardiology Center. Zhukovsky
Russian Federation


S. V. Belonosova
Moscow Regional Cardiology Center. Zhukovsky
Russian Federation


I. B. Ryzhikova
Moscow Regional Cardiology Center. Zhukovsky
Russian Federation


I. D. Bondarenko
Moscow Regional Cardiology Center. Zhukovsky
Russian Federation


O. V. Patrikhalkina
Moscow Regional Cardiology Center. Zhukovsky
Russian Federation


References

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Review

For citations:


Pozdnyakov Yu.M., Urinsky A.M., Kuznetsov R.L., Belonosova S.V., Ryzhikova I.B., Bondarenko I.D., Patrikhalkina O.V. Еprosartan therapy effectiveness in arterial hypertension patients after stroke or transient ischemic attack. Cardiovascular Therapy and Prevention. 2006;5(6):32-36. (In Russ.)

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)