Hypolipidemic effectiveness and safety of generic lovastatin
Abstract
Aim. To study hypolipidemic effectiveness and safety of generic lovastatin (Cardiostatin®). Material and methods. This open, cooperative study included 90 patients with coronary heart disease (CHD) and hypercholesterolemia (<10 mmol/l). All patients received Cardiostatin® in the dose of 20 mg/d, increased up to 40-80 mg/d, if needed. Dynamics of total cholesterol (TCH), low-density lipoprotein CH (LDL-CH), high-density lipoprotein CH (HDL-CH), triglycerides, hepatic enzymes, and C-reactive protein (CRP) levels was studied. Results. Cardiostatin® improved lipid profile to the same extent as original lovastatin. Target TCH level (<2,5 mmol/l) was achieved in 68,8% of the patients. In participants with initially increased CRP level, it had significantly reduced. Conclusion. Cardiostatin® demonstrated good hypolipidemic effects, at the same time reducing increased CRP level. Cardiostatin can be recommended for dyslipidemia and atherosclerotic pathology treatment.
About the Authors
D. M. Aronov
State Research Center for Preventive Medicine, State Federal Agency for Health and Social Development
Russian Federation
Russian Federation
V. V. Kukharchuk
A.L. Myasnikov Research Institute of Clinical Cardiology, Russian Cardiology Scientific and Clinical Complex, State Federal Agency for Health and Social Development
Russian Federation
Russian Federation
V. G. Kukes
I.M. Sechenov Moscow Medical Academy, State Federal Agency for Health and Social Development. Moscow
Russian Federation
Russian Federation
M. G. Bubnova
State Research Center for Preventive Medicine, State Federal Agency for Health and Social Development
Russian Federation
Russian Federation
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Review
For citations:
Aronov D.M., Kukharchuk V.V., Kukes V.G., Bubnova M.G. Hypolipidemic effectiveness and safety of generic lovastatin. Cardiovascular Therapy and Prevention. 2006;5(6):46-52. (In Russ.)
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