Statins in arterial hypertension treatment
Abstract
Aim. To analyse cardiovascular risk levels in patients with arterial hypertension (AH); to assess atorvastatin effectiveness in AH patients without cardiovascular events (CVE).
Material and methods. In total, 612 CVE-free patients with AH were examined. The participants with SCORE risk level of 5-9% received atorvastatin (10 mg/d) and standard antihypertensive therapy. The authors examined the effects of atorvastatin on blood pressure levels, lipid profile, endothelium-dependent vasodilatation (EDVD) in the brachial artery reactive hyperemia test, intima-media thickness (IMT) of common carotid arteries, C-reactive protein (CRP) concentration, and heart rate variability (HRV).
Results. At the end of the study, the atorvastatin group demonstrated a significant decrease in mean levels of total cholesterol (CH), low-density lipoprotein CH and CRP was observed, as well as an increase in EDVD. In addition, in the atorvastatin group, the reduction of sympathetic component of low-frequency and especially very low-frequency HRV was more manifested than in the standard therapy group. In CVE-free patients with AH, atorvastatin therapy (10 mg/d) effectively normalised lipid profile, neuro-humoral and sympatho-adrenal activity parameters, and also demonstrated anti-inflammatory effect.
Conclusion. The majority of AH patients have high and very high risk levels and, therefore, require a complex approach towards cardiovascular risk factor modification.
About the Authors
O. N. Tkacheva
V.I. Kulakov Scientific Centre for Obstetrics, Gynaecology, and Perinatology
Russian Federation
Russian Federation
Moscow
N. V. Sharashkina
V.I. Kulakov Scientific Centre for Obstetrics, Gynaecology, and Perinatology
Russian Federation
Russian Federation
Moscow
A. B. Barabashkina
V.I. Kulakov Scientific Centre for Obstetrics, Gynaecology, and Perinatology
Russian Federation
Russian Federation
Moscow
I. M. Novikova
V.I. Kulakov Scientific Centre for Obstetrics, Gynaecology, and Perinatology
Russian Federation
Russian Federation
Moscow
I. E. Mishina
V.I. Kulakov Scientific Centre for Obstetrics, Gynaecology, and Perinatology
Russian Federation
Russian Federation
Moscow
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Review
For citations:
Tkacheva O.N., Sharashkina N.V., Barabashkina A.B., Novikova I.M., Mishina I.E. Statins in arterial hypertension treatment. Cardiovascular Therapy and Prevention. 2009;8(7):43-48. (In Russ.)
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