Body weight dynamics and cardiovascular risk factors in climacteric women
Abstract
Aim. To compare body weight (BW), lipid and carbohydrate metabolism dynamics in premenopausal, menopausal, and postmenopausal women.
Material and methods. This cohort study included 573 volunteers aged 36-55 years. Mean follow-up period was 3,4 years. Anthropometric parameters, lipid and carbohydrate profiles, rates of arterial hypertension, coronary heart disease, chronic heart failure, myocardial infarction, and stroke were analyzed. All participants were divided into four groups: Group I – 104 women remaining in premenopause; Group II – 87 patients with developed menopause; Group III – 238 postmenopausal women; Group IV – 144 individuals in late postmenopause (>5 years).
Results. Maximal mean BW, waist circumference (WC) and their increase were registered in Group II. During the follow-up, significant BW increase was observed in Groups II and IV. Three years alter, carbohydrate metabolism disturbances become significantly more frequent, especially in Group IV. Substantial BW and WC increase was observed in all groups, among participants with newly diagnosed carbohydrate metabolism disturbances; median three-year dynamics was 2 kg and 2 cm, respectively.
Conclusion. Maximal BW and WC increase was observed during menopausal transition. In climacteric women, abdominal obesity was highly prevalent. Carbohydrate metabolism disturbance rate started to increase in menopause and continued to elevate in advanced age, being associated with BW increase (2 kg in 3 years).
About the Authors
A. A. Popov
Ural State Medical Academy
Russian Federation
Russian Federation
N. V. Izmozherova
Ural State Medical Academy
Russian Federation
Russian Federation
N. V. Tagiltseva
Ural State Medical Academy
Russian Federation
Russian Federation
A. N. Andreev
Ural State Medical Academy
Russian Federation
Russian Federation
O. Yu. Stryukova
Immunology and Physiology Institute, Ural Branch, Russian Academy of Sciences, Yekaterinburg
Russian Federation
Russian Federation
E. V. Kozulina
Ural State Medical Academy
Russian Federation
Russian Federation
References
1. Аметов А.С., Демидова И.Ю., Целиковская А.Л. Ожирение и сердечно-сосудистые заболевания. Тер архив 2001; 8: 66-9.
2. Оганов Р.Г., Перова Н.В., Метельская В.А Абдоминальное ожирение у больных артериальной гипертонией: атерогенные нарушения в системе транспорта липидов и обмена углеводов. РКЖ 2001; 31(5): 16-20.
3. Kannel WB, Cuppels LA, Ramaswami R, et al. M. Regional obesity and risk of cardiovascular disease; the Framingham study. J Clin Epidemiol 1991; 44(2): 183-90.
4. Репина М.А. Менопаузальный метаболический синдром и ожирение. Ж акуш жен бол 2003; 3: 75-84.
5. Kuh D, Langenberg C, Hardy R, et al. Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study. BJOG 2005; 112(4): 476-85.
6. Spencer CP, Godsland IF, Stevenson JC. Is there a menopausal metabolic syndrome. Gynecol Endocrinol 1997; 11(5): 341-55.
7. Toth MJ, Tchernof A, Sites CK, et al. Menopausal-related changes in body fat distribution. Ann J Acad Sci 2000; 904: 502-6.
8. Van den Brule F, Gaspard U. Body mass changes at menopause: impact of therapeutic strategies. Rev Med Liege 2003; 58(12): 734-40.
9. IDF. Barclay L. Medscape Medical News. New definition of the metabolic syndrome: a newsmaker interview with Sir George Alberti, MA, DPhil, BMBCh. Available at: http://www.med-scape.com/viewarticle/504382 Accessed July 8, 2005.
10. Сметник В.П., Ткаченко Н.М., Глезер Г.А., Москаленко Н.П. Климактерический синдром. Москва «Медицина» 1988; 288 с.
11. Российские рекомендации по профилактике, диагностике и лечению артериальной гипертензии. Разработаны Комитетом экспертов ВНОК. Приложение к журналу Кардиоваск тер профил 2004; 19 с.
12. Российские рекомендации по диагностике и лечению стабильной стенокардии. Разработаны Комитетом экспертов ВНОК. Приложение к журналу Кардиоваск тер профил 2004; 28 с.
13. Национальные рекомендации по диагностике и лечению ХСН. Ж серд недостат 2003; 4(6): 276-97.
14. WHO. Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diab Care 1999; 23(1): S4-16.
15. Executive summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 2001; 285 (19): 2486-97.
16. Российские рекомендации ВНОК «Диагностика и коррекция нарушений липидного обмена с целью профилактики и лечения атеросклероза» Москва 2005; 20 c.
17. Obesite: prevention et prise en charge de l epidemie mondiale: rapport d une Consultation de l OMS. Organisation mondiale de la Sante. Geneve 2003; 300.
18. Дедов И.И., Шестакова М.В., Максимова М.А. Федеральная целевая программа «Сахарный диабет». Методические рекомендации. Москва 2002; 92 c.
19. Matthews KA, Abrams B, Crawford S, et al. Body mass index in mid-life women: relative influence of menopause, hormone use, and ethnicity. Int J Obes Relat Metab Disord 2002; 26(8): 1150.
20. Milewicz A, Demissie M, Zatonska K, et al. Influence of dietary and genetic factors on metabolic status in obese and lean postmenopausal women. Gynecol. Endocrinology 2003; 17(4): 333-8.
21. Nicklas BJ, Penninx BW, Ryan AS, et al. adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women. Diabetes Care 2003; 26(5): 1413-20.
22. Walton C, Godsland IF, Proudler AJ, et al. The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women. Eur J Clin Invest 1993; 23: 466-73.
23. Kim HS, Abbasi F, Lamendola C, et al. Effect of insulin resistance on postprandial elevations of remnant lipoprotein concentrations in postmenopausal women. Am J Clin Nutr 2001; 74: 592-5.
24. Feldstein CA, Akopian M, Renauld A, et al. Insulin resistance and hypertension in postmenopausal women. J Hum Hypertens 2002; 16(Suppl. 1): S145-50.
25. Miller AM, Wilbur J, Chandler PJ, et al. Cardiovascular disease risk factors and menopausal status in midlife women from the former Soviet Union. Women Healthy 2003; 38: 19-36.
26. Bamford J, Sandercock P, Dennis M, et al. Prospective study of acute cerebrovascular disease in the community: the Oxfordshire community stroke project, 1981-1986, 1. Methodology, demography and incident cases of first ever stroke. J Neurol Neurosurg Psychiat 1988; 51: 1373-80.
27. Wilson PW, Kannell WB, Silbershatz H, D’Agostino RB. Clustering of metabolic factors and coronary heart disease. Arch Intern Med 1999; 159: 1104-9.
28. Омельяненко М.Г., Краснова Л.Г., Полятыкина Т.С. и др. Роль эндотелиальной дисфункции и метаболического синдрома в патогенезе ранней ишемической болезни сердца у женщин. Кардиоваск тер профил 2002; 1(1): 47-52.
Review
For citations:
Popov A.A., Izmozherova N.V., Tagiltseva N.V., Andreev A.N., Stryukova O.Yu., Kozulina E.V. Body weight dynamics and cardiovascular risk factors in climacteric women. Cardiovascular Therapy and Prevention. 2007;6(8):69-76. (In Russ.)
Views:
480
Email this article 
