PROGNOSTIC SIGNIFICANCE OF GALECTIN-3 MEASUREMENT IN PATIENTS WITH METABOLIC SYNDROME AND NON-ALCOHOLIC FATTY LIVER DISEASE
https://doi.org/10.15829/1728-8800-2015-5-40-47
Abstract
Aim. To assess the levels of serum fibrosis marker (galectin-3) in patients with metabolic syndrome (MS) and non-alcoholic fatty liver disease (NAFLD)
Material and methods. Totally 76 patients included, 43 with MS, of those 72,1% had the NAFLD diagnosed; 33 patients without MS and NAFLD (controls), mean age 61±12 y. The complex investigation was done, incl. the levels of galectin-3 measurement. Results. Mean level of galectin-3 in MS group was significantly higher than in controls (р=0,006). Left ventricle myocardium hypertrophy (LVH), chronic heart failure (CHF) were diagnosed significantly more frequently in MS group (р<0,05). Mean values of galectin-3 statistically more significantly higher were in CHF (р<0,05). Mean volumetric fibrosis fraction in interventricular septum was significantly higher in MS group than in non-MS (р<0,001). Of MS patients 72,1% had NAFLD. There were positive correlations of galectin-3 and the following: LVH (r=0,30), CHF (r=0,35), coronary heart disease (r=0,34), heart fibrosis fraction (r=0,24), liver steatosis (r=0,43) pancreas steatosis (r=0,24), NAFLD fibrosis score (r=0,30),— all р<0,05.
Conclusion. The study revealed correlations of the level of galectin-3 and the conditions closely associated with MS — LVH, CHF, fraction of heart fibrosis, liver and pancreas steatosis. In all MS patients the galectin-3 values were significantly higher that can be regarded as the witness of more prominent fibrosis of the heart and the liver. Serum fibrosis marker (galectin-3) might be promising molecule for assessment of the patient condition in MS and be used as an additional criteria for diagnostics of cardiovascular catastrophes and, probably, of liver pathology — NAFLD.
About the Authors
O. M. Drapkina
FSBI "State Scientific-Research Center of the Preventive Medicine" of the Healthcare Ministry, Moscow, Russia; SBEI HPE "First Moscow State Medical University n.a. I. M. Sechenov" of the Healthcare Ministry. Moscow, Russia
Russian Federation
Russian Federation
T. A. Deeva
SBEI HPE "First Moscow State Medical University n.a. I. M. Sechenov" of the Healthcare Ministry. Moscow, Russia
Russian Federation
Russian Federation
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Review
For citations:
Drapkina O.M., Deeva T.A. PROGNOSTIC SIGNIFICANCE OF GALECTIN-3 MEASUREMENT IN PATIENTS WITH METABOLIC SYNDROME AND NON-ALCOHOLIC FATTY LIVER DISEASE. Cardiovascular Therapy and Prevention. 2015;14(5):40-47. (In Russ.) https://doi.org/10.15829/1728-8800-2015-5-40-47
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