Hyperhomocysteinemia, C-677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene, and chronic arterial hypertension in pregnant women
https://doi.org/10.15829/1728-8800-2012-1-41-44
Abstract
Aim. To investigate the prevalence of C-677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene and hyperhomocysteinemia (HHC) in pregnant women with chronic arterial hypertension (CAH).
Material and methods. This prospective cohort study included two groups: Group I – pregnant women with CAH (n=80), and Group II – pregnant women without AH (n=40). In all participants, homocysteine (HC) levels were assessed using immunoenzymatic method, at 9-12 weeks, 22-24 weeks, and 30-32 weeks. Genotyping of the C-677T polymorphism of MTHFR gene was performed using polymerase chain reaction.
Results. In pregnant women with CAH, HC levels were higher than in women without AH, throughout the pregnancy. Group I also demonstrated higher prevalence of T allele and T/C genotype. In pregnant women with HHC, relative risk (RR) of pre-eclampsia was 3,5 (95% CI 2,0-5,6), of chronic placental insufficiency - 1,2 (95% CI 0,9-1,6), and of intrauterine growth restriction syndrome - 6,4 (95% CI 3,1-13,3).
Conclusion. HCC, as well as its combination with C-677T polymorphism of MTHRF gene, could be regarded as a biomarker of complicated pregnancy in women with CAH.
About the Authors
V. S. Chulkov
Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
N. K. Vereina
Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
S. P. Sinitsyn
Chelyabinsk State Medical Academy, Chelyabinsk
Russian Federation
Russian Federation
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Review
For citations:
Chulkov V.S., Vereina N.K., Sinitsyn S.P. Hyperhomocysteinemia, C-677T polymorphism of methylenetetrahydrofolate reductase (MTHFR) gene, and chronic arterial hypertension in pregnant women. Cardiovascular Therapy and Prevention. 2012;11(1):41-44. (In Russ.) https://doi.org/10.15829/1728-8800-2012-1-41-44
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