ACE inhibitor effects of brachial artery structure and function in patients with arterial hypertension
https://doi.org/10.15829/1728-8800-2012-2-35-38
Abstract
Aim. To investigate the effects of an angiotensin-converting enzyme (ACE) inhibitor fosinopril on the structural and functional parameters of brachial arteries (BA) in patients with essential arterial hypertension (EAH).
Material and methods. The study included 32 EAH patients: 15 men and 17 women aged 27-59 years (mean age 45,6±11,7 years). BA ultrasound and echocardiography (EchoCG) were performed with the use of the Vivid 7 Dimension device (USA). The following parameters of BA remodelling were analysed: intima-media thickness (IMT), lumen diameter (D), and wall-to-lumen (W/L) ratio. BA endotheliumdependent vasodilatation (EDVD) was assessed in the reactive hyperemia test. Central hemodynamic parameters were also assessed.
Results. In EAH patients, the six-month fosinopril treatment was associated with BA IMT reduction, but not with substantial intraluminal diameter changes, or increased endothelium-dependent vasodilatation.
Conclusion. Among EAH patients, an ACE inhibitor fosinopril demonstrated a marked improvement in BA structural and functional parameters.
About the Author
L. V. Melnikova
Penza University of Medical Post-Diploma Education, Penza
Russian Federation
Russian Federation
References
1. Shalnova S.A., Deev A.D., Vihireva O.V., et al. The prevalence of hypertension in Russia. Informativeness, treatment and control. Profil zabol ukrep zdor 2001; 2: 3-7. Russian (Шальнова С.А., Деев А.Д., Вихирева О В. и др. Распространенность артериальной гипертонии в России. Информативность, лечение, контроль. Профил забол укреп здор 2001; 2: 3-7).
2. Bojcov A. Vessels as a base and a target of hypertension. Bol serd sosud 2006; 3: 35-40. Russian (Бойцов А. Сосуды как плацдарм и мишень артериальной гипертонии. Бол серд сосуд 2006; 3: 35-40).
3. Celermajer D.S., Sorensen K.E., Gooch V.M., et al. Noninvasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 8828.
4. Wetinin V.V., Beresten’ N.F. Cardioconcording dopplerosonography. M.: Medicina 2002: 240 p. Russian (Щетинин В.В., Берестень Н.Ф. Кардиосовместимая допплерография. М.: Медицина 2002; 240 с).
5. Bonithon-Kopp C., Ducimetiere P., Touboul P.-J., et al. Plasma angiotensin-converting enzyme activity and carotid wall thickening. Circulation 1994; 89: 952-4.
6. Sidorenko V.A., Preobrazhenskij D.V. The range of clinical applications of angiotensin-converting enzyme inhibitor quinapril. Kardiologija 1998; 3: 85-90. Russian (Сидоренко В.А., Преображенский Д.В. Диапазон клинического применения ингибитора ангиотензин-превращающего фермента квинаприла. Кардиология 1998; 3: 85-90).
7. Mancini G.В.J., Henry G.P., Macay C., et al. Angiotensin converting enzyme inhibition with quinapril improves endothеlial vasomotor dysfunction in patients with coronary artery disease. The TREND study. Circulation 1996; 94: 258-65.
8. Filatova E.V., Vihert O.A., Rogoza N.M., et al. Comparison of the effect of Capoten (captopril) and ramipril on the circadian blood pressure and peripheral hemodynamics in patients with arterial hypertension combined with diabetes mellitus. Ter arhiv 1996; 68(5): 67-70. Russian (Филатова Е.В., Вихерт О.А., Рогоза Н.М. и др. Сравнение влияния капотена (каптоприла) и рамиприла на суточный профиль артериального давления и периферическую гемодинамику больных гипертонической болезнью в сочетании с сахарным диабетом. Тер архив 1996; 68(5): 67-70).
9. Chernov Ju.N., Batiweva G.A., Provorotov V.M., et al. ACE inhibitors: characteristics of clinical application. V mire lekarstv 1999; 1: 13-21. Russian (Чернов Ю.Н., Батищева Г.А., Проворотов В.М. и др. Ингибиторы АПФ: особенности клинического применения. В мире лекарств 1999; 1: 13-21).
10. Anderson T.J., Elstein E., Haber H., et al. Comparative study of ACE-Inhibition, angiotensin II antagonism, and calcium channel blockade on flow mediated vasodilatation in patients with coronary disease (BANFF Study). JACC 2000; 35: 60-6.
11. Krasnova E.A. Fozikard in the treatment of hypertension. RMZ 2006; 14(4): 230-4. Russian (Краснова Е.А. Фозикард в лечении артериальной гипертензии. РМЖ 2006; 14 (4): 230-4).
12. Balkarov I.M., Shonichev D.G., Kozlova V.G. Some approaches to improve the quality of treatment for patients with hypertension. Ter arhiv 2000; 1: 47. Russian (Балкаров И.М., Шоничев Д.Г., Козлова В.Г. Некоторые подходы к повышению качества лечения пациентов с артериальной гипертензией. Тер архив 2000; 1: 47).
Review
For citations:
Melnikova L.V. ACE inhibitor effects of brachial artery structure and function in patients with arterial hypertension. Cardiovascular Therapy and Prevention. 2012;11(2):35-38. (In Russ.) https://doi.org/10.15829/1728-8800-2012-2-35-38
Views:
503
Email this article 
