Hemostasis protein-coding genes, peripheral hemostasis parameters, and atherothrombosis predisposition in patients with cardiovascular disease
https://doi.org/10.15829/1728-8800-2011-4-90-95
Abstract
Aim. To study the associations between polymorphic variants of hemostasis protein-coding genes, hemostasis system functioning, and atherothrombosis development in patients with cardiovascular disease (CVD).
Material and methods. The study included 76 patients. Polymorphic gene marker alleles were analyzed by PCRPDRF method.
Results. The genotype prevalence was assessed for the polymorphic variants of F V, F II, Gp Iα, Gp IIIα, Gp Iβα, PAI-1, and FBG genes. In CVD patients, a polymorphic variant 4G (-675)5G of PAI-1 gene was associated with peripheral hemostasis disturbances.
Conclusion. 5G allele of PAI-1 gene was associated with higher plasminogen concentration and lower PAI-1 levels, which resulted in reduced plasma thrombogenicity.
About the Authors
G. I. Lifshits
Research Institute of Chemical Biology and Basic Medical Science, Siberian Division of the Russian Academy of Medical Sciences
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
S. T. Danilkina
New Medical Technologies Centre, Academgorodok
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
E. V. Guskova
Research Institute of Chemical Biology and Basic Medical Science, Siberian Division of the Russian Academy of Medical Sciences
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
E. N. Voronina
Research Institute of Chemical Biology and Basic Medical Science, Siberian Division of the Russian Academy of Medical Sciences
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
M. L. Filipenko
Research Institute of Chemical Biology and Basic Medical Science, Siberian Division of the Russian Academy of Medical Sciences
Russian Federation
Novosibirsk
Russian Federation
Novosibirsk
References
1. Бокарев И. Н. Атеротромбоз — 2001. Атеротромбоз, артериальная гипертензия. Москва 2001; 70-3.
2. Пузырев В.П., Степанов В.А., Макеева О.А. Синтропные гены болезней сердечно-сосудистого континуума. Мед генетика 2009; 3: 31-8.
3. Baranovskaya S, Kudinov S, Fomicheva E, et al. Age as a risk factor for myocardial infarction in Leiden mutation carriers. Mol Genet Metab 1998; 64(2): 155-7.
4. Doggen CJ, Cats VM, Bertina RM, Rosendaal FR. Interaction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A. Circulation 1998; 97: 1037-41.
5. Сироткина О.В., Баженова Е.А., Беркович О.Ф., Пчелина С.Н. Сочетанное носительство аллельных вариантов генов системы тромбообразования как фактор риска развития инфаркта миокарда у мужчин молодого возраста. Материалы конгресса “Российская кардиология: от центра к регионам”. Приложение 2. Кардиоваск тер профил 2004; 4: 447-8.
6. Folsom AR, Aleksic N, Ann C, et al. Beta-fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: the Atherosclerosis Risk in Communities (ARIC) Study. Ann Epidemiol 2001; 11: 3: 166-70.
7. Lijnen HR. Pleiotropic functions of plasminogen activator inhibitor-1. J Thromb Haemost 2004; 3: 35-45.
8. Berne G, Heinrich J, Schulte H, et al. Association of the GPIa C807T and GPIIIa P1A1/A2 polymorphisms with premature myocardial infarction in men. Eur Heart J 2002; 23(6): 325-30.
9. Donahue BS, Byrne DW, Gailani D, George AL. Tissue Factor and Platelet Glycoprotein Ib-б Alleles Are Associated with Age at First Coronary Bypass Operation. Anesthesiology 2003; 99: 1287-94.
10. Frank MB, Reiner AP, Schwartz SM, et al. The Kozak sequence polymorphism of platelet glycoprotein Iba and risk of nonfatal myocardial infarction and nonfatal stroke in young women. Blood 2001; 97: 875-9.
11. Lagercrantz J, Bergman AC, Lundman P, et al. No evidence that the PLA1/PLA2 polymorphism of platelet glycoprotein IIIa is implicated in angiographically characterized coronary atherosclerosis and premature myocardial infarction. Blood Coagul Fibrinol 2003; 14(8): 749-53.
12. Mikkelsson J, Perola M, Penttild A, et al. The GPIIIa (P5 integrin) P1A polymorphism in the early development of coronary atherosclerosis. Atherosclerosis 2001; 154: 721-7.
13. Ardissino D, Mannucci PM, Merlini PA, et al. Prothrombotic genetic risk factors in young survivors of myocardial infarction. Blood 1999; 94(1): 46-51.
14. Atherosclerosis, Thrombosis, and Vascular Biology Italian Study Group. No Evidence of Association Between Prothrombotic Gene Polymorphisms and the Development of Acute Myocardial Infarction at a Young Age. Circulation 2003; 107: 1117.
15. Winkelmann BR, Hager J, Kraus WE, et al. Genetics of coronary heart disease: Current knowledge and research principles. Am Heart J 2000; 140(4): S11-26.
16. Roest Crollius H, Jaillon O, Bernot A, et al. Estimate of human gene number provided by genome-wide analysis using DNA sequence. Nat Genetics 2000; 25: 235-8.
17. Grant PJ. Polymorphisms of coagulation/fibrinolysis genes: gene environment interactions and vascular risk. Prostaglandins Leukot Essent Fatty Acids 1997; 57: 473-7.
18. McCarthy JJ, Parker A, Salem R, et al. Large scale association analysis for identification of genes underlying premature coronary heart disease: cumulative perspective from analysis of 111 candidate genes. J Med Genet 2004; 41: 334-41.
Review
For citations:
Lifshits G.I., Danilkina S.T., Guskova E.V., Voronina E.N., Filipenko M.L. Hemostasis protein-coding genes, peripheral hemostasis parameters, and atherothrombosis predisposition in patients with cardiovascular disease. Cardiovascular Therapy and Prevention. 2011;10(4):90-95. (In Russ.) https://doi.org/10.15829/1728-8800-2011-4-90-95
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