A NEW COMBINATION INHIBITS INTESTINAL CHOLESTEROL ABSORPTION, SUPPRESSES ENDOGENOUS CHOLESTEROL SYNTHESIS, AND DEMONSTRATES ANTI-INFLAMMATORY AND HEPATOPROTECTIVE EFFECTS
https://doi.org/10.15829/1728-8800-2013-3-63-67
Abstract
Hypercholesterolemia (HCH) and vascular inflammation are the main therapeutic targets in atherosclerosis. The paper discusses the results of the studies which have focussed on the effects of a new class of physiologically active substances (polyprenols and β-sitosterols) on lipid profile and pro-inflammatory cytokines in HCH patients with low to moderate cardiovascular risk. Polyprenol phosphates and phytosterols could help to achieve significant changes in lipid profile and normalisation of immunologic parameters.
About the Authors
R. G. Oganov
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
S. I. Chernova
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
V. Yu. Gorbacheva
State Research Centre for Preventive Medicine, Moscow
Russian Federation
Russian Federation
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Review
For citations:
Oganov R.G., Chernova S.I., Gorbacheva V.Yu. A NEW COMBINATION INHIBITS INTESTINAL CHOLESTEROL ABSORPTION, SUPPRESSES ENDOGENOUS CHOLESTEROL SYNTHESIS, AND DEMONSTRATES ANTI-INFLAMMATORY AND HEPATOPROTECTIVE EFFECTS. Cardiovascular Therapy and Prevention. 2013;12(3):63-67. (In Russ.) https://doi.org/10.15829/1728-8800-2013-3-63-67
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