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Кардиоваскулярная терапия и профилактика

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Антагонисты АТ1-рецепторов ангиотензина II, ингибиторы ангиотензин-превращающего фермента в регуляции гемодинамики и активности ренинангиотензин-альдостероновой системы. Фокус на органопротективные эффекты

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Аннотация

При длительной активации ренин-ангиотензин-альдостероновой системы (РААС) отмечается вазоконстрикция, повышение общего периферического сопротивления сосудов, гипоперфузия органов и тканей, задержка жидкости, увеличение объема циркулирующей крови, повышение чувствительности миокарда к токсическому влиянию катехоламинов, ремоделирование миокарда и сосудов, развитие миокардиального и периваскулярного фиброза. Снижение активности РААС может быть обеспечено либо подавлением синтеза ангиотензина II, либо блокадой АТ1-рецепторов. Ингибиторы ангиотензин-превращающего фермента (ИАПФ) представляют собой высокоэффективные препараты, широко используемые в лечении сердечно-сосудистых заболеваний: артериальной гипертонии, хронической сердечной недостаточности, ишемической болезни сердца. Основными фармакологическими эффектами ИАПФ являются гемодинамические, нейрогуморальные, антипролиферативные, кардио- и нефропротективный, а также улучшение эндотелиальной функции. Для антагонистов АТ1-рецепторов характерны высокая антигипертензивная эффективность, великолепная переносимость, органопротективные свойства, простота использования и отсутствие значимых взаимодействий с другими лекарствами, что незаменимо в повседневной практике клинициста.

Об авторах

М. Л. Максимов
ГОУ ВПО Московская медицинская академия имени И.М. Сеченова Росздрава. Москва
Россия
доцент кафедры клинической фармакологии и пропедевтики внутренних болезней


О. В. Дралова
ГОУ ВПО Московская медицинская академия имени И.М. Сеченова Росздрава. Москва
Россия
аспирант кафедры клинической фармакологии и пропедевтики внутренних болезней


А. К. Стародубцев
ГОУ ВПО Московская медицинская академия имени И.М. Сеченова Росздрава. Москва
Россия
профессор кафедры клинической фармакологии и пропедевтики внутренних болезней


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Для цитирования:


Максимов М.Л., Дралова О.В., Стародубцев А.К. Антагонисты АТ1-рецепторов ангиотензина II, ингибиторы ангиотензин-превращающего фермента в регуляции гемодинамики и активности ренинангиотензин-альдостероновой системы. Фокус на органопротективные эффекты. Кардиоваскулярная терапия и профилактика. 2010;9(2):115-124.

For citation:


Maksimov M.L., Dralova O.V., Starodubtsev A.K. Angiotensin II type 1 receptor antagonists and ACE inhibitors in the regulation of hemodynamics and renin-angiotensin-aldosterone system activity: focus on the organ protection. Cardiovascular Therapy and Prevention. 2010;9(2):115-124. (In Russ.)

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