Subclinical thyroid pathology and atrial fibrillation development in patients with coronary heart disease and arterial hypertension
Abstract
Aim. To study the structural and functional characteristics of thyroid gland (TG) in patients with coronary heart disease (CHD) and arterial hypertension (AH), in regard to the presence of atrial fibrillation (AF).
Material and methods. The study included 90 patients aged over 50 years, with CHD and AH; 60 patients also had AF. All participants underwent TG ultrasound, assessment of blood levels of thyroid hormones, thyrotropin (TT), anti-thyroid antibodies, and echocardiography (EchoCG). The patients were residents of an iodine-deficient region.
Results. In patients with AF, increased TG size and multi-nodal TG pathology were significantly more prevalent, and free thyroxin (T4f) levels were significantly higher than in AF-free participants (especially in women and individuals with increased TG size). Patients with AF and multi-nodal TG pathology demonstrated a significantly increased TG volume and decreased TT levels. Based on EchoCG data, these patients also had significantly lower atrial and left ventricular sizes, as well as a higher ejection fraction, compared to the patients with solitary TG nodes.
Conclusion. In AF patients, increased TG function could be explained by functional TG autonomy, especially among individuals with multi-nodal thyroid pathology.
About the Authors
E. A. Mayskova
V. I. Razumovskyi Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
E. V. Pushkareva
V. I. Razumovskyi Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
E. A. Fedotov
V. I. Razumovskyi Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
Yu. G. Schwarz
V. I. Razumovskyi Saratov State Medical University
Russian Federation
Saratov
Russian Federation
Saratov
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Review
For citations:
Mayskova E.A., Pushkareva E.V., Fedotov E.A., Schwarz Yu.G. Subclinical thyroid pathology and atrial fibrillation development in patients with coronary heart disease and arterial hypertension. Cardiovascular Therapy and Prevention. 2011;10(8):4-9. (In Russ.)
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