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Кардиоваскулярная терапия и профилактика

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Клиническая фармакология комбинации ингибиторов ангиотензин-превращающего фермента и антагонистов кальция: преимущества комбинации периндоприла аргинина и амлодипина

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Аннотация

Представлены современные данные по механизмам действия и клинической эффективности двух классов кардиоваскулярных препаратов – ингибиторов ангиотензин-превращающего фермента (ИАПФ) и антагонистов кальция (АК), в аспекте их применения у пациентов с артериальной гипертонией (АГ) и ишемической болезнью сердца (ИБС). ИАПФ и АК обладают комплементарным механизмом действия на тонус сосудов и дисфункцию эндотелия, обеспечивают синергизмом действия в снижении артериального давления (АД), а также в достижении плейотропных и органопротективных эффектов, уменьшении развития неблагоприятных исходов, что обосновывает предпосылки для их сочетанного применения в лечении кардиоваскулярных заболеваний. Наибольшее практическое значение и доказательную базу имеют периндоприл и амлодипин, применяющиеся как в монотерапии, так и в виде комбинации.

Об авторе

М. В. Леонова
ГОУ ВПО Российский государственный медицинский университет Росздрава. Москва
Россия
профессор кафедры клинической фармакологии


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Для цитирования:


Леонова М.В. Клиническая фармакология комбинации ингибиторов ангиотензин-превращающего фермента и антагонистов кальция: преимущества комбинации периндоприла аргинина и амлодипина. Кардиоваскулярная терапия и профилактика. 2010;9(8):55-62.

For citation:


Leonova M.V. Clinical pharmacology of the combination of ACE inhibitors and calcium antagonists: benefits of the perindopril arginine and amlodipine combination. Cardiovascular Therapy and Prevention. 2010;9(8):55-62. (In Russ.)

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)