CALCIUM CHANNEL BLOCKADE AND FUNCTIONAL MICROCIRCULATION CHANGES IN HYPERTENSIVE PATIENTS WITH DIFFERENT INDIVIDUAL AND TYPOLOGICAL CHARACTERISTICS
https://doi.org/10.15829/1728-8800-2013-5-4-10
Abstract
Aim. To identify individual and typological functional features of peripheral blood flow and assess microcirculation (MC) dynamics after a single-dose administration of nifedipine in patients with arterial hypertension (AH).
Material and methods. Laser Doppler flowmetry (LDF) was used for the MC assessment in 39 patients with Stage II–III AH.
Results. Marked variability in peripheral blood flow parameters was demonstrated for AH patients. Three main LDF types were identified: aperiodic (ApT), hyperemic, and hypoemic. Single-dose administration of nifedipine (20 mg) resulted in a similar antihypertensive effect across all patient groups. Positive MC dynamics was observed, which manifested in a marked increase in the number of patients with ApT (the most balanced type of peripheral blood flow regulation) and increased input of pulse blood filling into hemoperfusion.
Conclusion. In AH patients, nifedipine-induced changes in peripheral blood flow were associated with an increased number of participants with ApT, as the most balanced type of MC regulation.
About the Authors
A. P. Vasiliev
Research Institute of Cardiology, Tumen Cardiology Centre, Siberian Branch of the Russian Academy of Medical Sciences, Tumen
Russian Federation
tel.: (3452) 20–73–86
Russian Federation
tel.: (3452) 20–73–86
N. N. Streltsova
Research Institute of Cardiology, Tumen Cardiology Centre, Siberian Branch of the Russian Academy of Medical Sciences, Tumen
Russian Federation
Russian Federation
E. A. Shumeiko
Research Institute of Cardiology, Tumen Cardiology Centre, Siberian Branch of the Russian Academy of Medical Sciences, Tumen
Russian Federation
Russian Federation
References
1. Pharmacological regulation of vascular tone. Galenko-Jaroshevskij P.A. (red). M.: Izdatelstvo RAMN 1999; 608 p. Russian (Фармакологическая регуляция тонуса сосудов. Галенко-Ярошевский П.А. (ред). М.: Издательство РАМН 1999; 608 c).
2. Zajchik ASh, Churilov LP. General pathology. Spb.: JeLBI-SPb 2001; 624 p. Russian (Зайчик А.Ш., Чурилов Л.П. Общая патология. Спб.: ЭЛБИ- СПб 2001; 624 с).
3. Microcirculation in cardiology. Makolkin V.I. (red). M.: “Vizart” 2004; 36 p. Russian (Микроциркуляция в кардиологии. Маколкин В.И. (ред). М.: “Визарт” 2004; 36 c).
4. Levy B. I. Microcirculation in hypertension: therapeutic implication. Medicographia 1999; 21:1: 62–4.
5. Schmid-Schonbein GW. What is relevance of microcirculation in cardiovascular disease? In: Microcirculation in cardiovascular disease. Lippincot Williams & Wilkins 2000; 1–13.
6. Bran’ko VV, Vahljaev VD, Bogdanova JeA. Application of laser Doppler flowmetry in cardiology. Russian Medical Journal 1998; 3:34–8. Russian (Бранько В.В., Вахляев В.Д., Богданова Э.А. Применение лазерной допплеровской флоуметрии в кардиологии. Российский медицин- ский журнал 1998; 3:34–8).
7. Laser Doppler flowmetry of microcirculation. Krupatkin A.I., Sidorov V.V. (red). M.: “Medicina” 2005; 256 p. Russian (Лазерная допплеровская флоуметрия микроциркуляции крови. Крупаткин А.И., Сидоров В.В. (ред). М.: “Медицина” 2005; 256 с).
8. Yvonne-Tee GB, Ghulam Rasool AN, Sukari Halim А, et al. Noninvasive assessment of cutaneous vascular function in vivo using capillaroscopy, prethysmography and laser-Doppler instruments: lts strengths and weaknesses. Clinical Hemorheology and Microcirculation 2006; 34:473–7.
9. Makolkin VI, Podzolkov VI, Pavlov VI i dr. The state of microcirculation in arterial hypertension. Cardiology 2003; 5:56–67. Russian (Маколкин В.И., Подзолков В.И., Павлов В.И. и др. Состояние микроциркуляции при гипертонической болезни. Кардиология 2003; 5:56–67).
10. Belgaro G, Laurora G, Cesarone M, et al. Microcirculation in high perfusion microangiopathy. J Cardiovasc Sugn (Torino) 1995; 36:393–8.
11. Bongard O, Bounameaux H. Clinical investigations of skin microcirculation. Dermatology 1993; 186: 6–11.
12. Kozlov VI, Azizov GA. Ibragimov R.H., i dr. Individual and typological characteristics of microcirculation in human beings. Regional Haemodynamics and Microcirculation 2005; 1 (13):77–8. Russian (Козлов В. И., Азизов Г.А. Ибрагимов Р.Х., и др. Индивидуально-типологические особенности микроциркуляции у человека. Регионарное кровообращение и микроциркуляция 2005; 1 (13):77–8).
13. Litvin FB. Morphofunctional alterations of the microcirculatory system in children, teenagers and young adults living in different radio-ecological conditions. Avtoref. diss… doktora biologich. nauk. Moskva 2006; 37 p. Russian (Литвин Ф.Б. Морфофункциональная перестройка системы микроциркуляции у детей подростков и юношей, проживающих в условиях с разными радиоэкологическими условиями. Автореф дисс доктора биол наук. Москва 2006; 37 с).
14. Vasil’ev AP, Strel’cova NN, Sekisova MA. Functional characteristics of microcirculation and their prognostic value in patients witharterial hypertension. Cardiovascular Therapy and Prevention 2011; 10 (5): 14–9. Russian (Васильев А.П., Стрельцова Н.Н., Секисова М.А. Функциональные особенности микроциркуляторной картины у больных артериальной гипертонией и их прогностическое значение. Кардиоваскулярная терапия и профилактика 2011; 10 (5):14–9).
15. Chujan EN, Tribrat NS, Anachenko MN. Individual and typological characteristics of microcirculatory parameters. Proceedings of Taurida National V.I. Vernadsky University. Series: Biology, chemistry 2008; 3 (21) (60): 190–203. Russian (Чуян Е. Н., Трибрат Н. С., Аначенко М.Н. Индивидуально-типологические особенности показателей микроциркуляции. Ученые записки Таврического национального университета им. В. И. Вернадского. Серия “Биология, химия” 2008; 3 (21) (60):190–203).
16. Levy BI, Ambrosio G, Pries AR, et al. Microcirculation in hypertension. A new target for treatment? Circulation 2001; 104:735–40.
17. Struijker Boudier HAJ. Hypertension and the microcirculation. In: Kaplan N., ed. Hypertension, microcirculation and end organ damage. London; Lippincot Williams & Wilkins. 2002:49–55.
Review
For citations:
Vasiliev A.P., Streltsova N.N., Shumeiko E.A. CALCIUM CHANNEL BLOCKADE AND FUNCTIONAL MICROCIRCULATION CHANGES IN HYPERTENSIVE PATIENTS WITH DIFFERENT INDIVIDUAL AND TYPOLOGICAL CHARACTERISTICS. Cardiovascular Therapy and Prevention. 2013;12(5):4-10. (In Russ.) https://doi.org/10.15829/1728-8800-2013-5-4-10
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