КОМБИНИРОВАННАЯ ТЕРАПИЯ В ЛЕЧЕНИИ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИ: ЭФФЕКТИВНОСТЬ СОЧЕТАНИЯ ЛЕРКАНИДИПИНА И ЭНАЛАПРИЛА
https://doi.org/10.15829/1728-8800-2013-5-75-80
Аннотация
Представлены доказательства преимуществ использования фиксированных комбинаций в лечении артериальной гипертонии. Рассмотрены возможности комбинированной терапии с использованием дигидропиридинового антагониста кальция 3 поколения лерканидипина и ингибитора ангиотензинпревращающего фермента эналаприла. Лерканидипин отличается высокой вазоселективностью и липофильностью, хорошей антигипертензивной эффективностью, большой длительностью и постепенным наступлением эффекта. Приведены имеющиеся в литературе доказательства эффективности комбинации лерканидипин/эналаприл. Эта комбинация дает возможность для достижения более выраженного снижения артериального давления, в т. ч. и у больных пожилого возраста, пациентов с сахарным диабетом и ожирением. Сочетание фармакологических эффектов лерканидипина и эналаприла создает дополнительные возможности для органопротекции и снижения риска побочных эффектов лечения.
Об авторе
Л. О. Минушкина
ФГБУ “Учебно-научный медицинский центр” УД Президента РФ, Москва
Россия
Россия
профессор кафедры терапии, кардиологии и функциональной диагностики
Тел.: 7 (499) 146–41–51; факс +7 (499) 144–16–34
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Рецензия
Для цитирования:
Минушкина Л.О. КОМБИНИРОВАННАЯ ТЕРАПИЯ В ЛЕЧЕНИИ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИ: ЭФФЕКТИВНОСТЬ СОЧЕТАНИЯ ЛЕРКАНИДИПИНА И ЭНАЛАПРИЛА. Кардиоваскулярная терапия и профилактика. 2013;12(5):75-80. https://doi.org/10.15829/1728-8800-2013-5-75-80
For citation:
Minushkina L.O. COMBINATION THERAPY IN THE MANAGEMENT OF ARTERIAL HYPERTENSION: EFFECTIVENESS OF THE LERCANIDIPINE AND ENALAPRIL COMBINATION. Cardiovascular Therapy and Prevention. 2013;12(5):75-80. (In Russ.) https://doi.org/10.15829/1728-8800-2013-5-75-80
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