Bioresource collection of biosamples from pregnant women at different gestational ages for the search for early biomarkers of pregnancy complications and potential for its use in research
https://doi.org/10.15829/1728-8800-2022-3399
Abstract
Aim. Clinical and anamnestic characterization of the bioresource collection of biosamples from pregnant women at different gestational ages.
Material and methods. Preparation of biosamples of various biomaterial types for long-term storage; static analysis of clinical and anamnestic characteristics of women whose samples are included in the collection.
Results. As of September 1, 2022, the collection consists of 16625 biosamples of various biomaterial types from 355 pregnant women. The clinical and anamnestic characteristics of women, samples of which are presented in the collection, are presented.
Conclusion. The resulting high-quality biosamples can be used in various basic and applied research to study both the physiological and pathological course of pregnancy. Particularly promising is the possibility of searching for the earliest biomarkers of gestational complications before the onset of obstetric complications. In this regard, it is important to have complete clinical and anamnestic data on biosamples of the collection in order to expand the possibilities of its use and improve the quality of ongoing research.
About the Authors
O. V. PachuliaRussian Federation
Saint-Petersburg
R. A. Illarionov
Russian Federation
Saint-Petersburg
E. S. Vashukova
Russian Federation
Saint-Petersburg
A. R. Maltseva
Russian Federation
Saint-Petersburg
T. B. Postnikova
Russian Federation
Saint-Petersburg
Yu. A. Nasykhova
Russian Federation
Saint-Petersburg
O. N. Bespalova
Russian Federation
Saint-Petersburg
A. S. Glotov
Russian Federation
Saint-Petersburg
References
1. Anisimov SV, Meshkov AN, Glotov AS, et al. National Association of Biobanks and Biobanking Specialists: New Community for Promoting Biobanking Ideas and Projects in Russia. Biopreserv Biobank. 2021;19(1):73-82. doi:10.1089/bio.2020.0049.
2. Payne P. Including Pregnant Women in Clinical Research: Practical Guidance for Institutional Review Boards. Ethics Hum Res. 2019;41(6):35-40. doi:10.1002/eahr.500036.
3. González-Duarte A, Zambrano-González E, Medina-Franco H, et al. The research ethics involving vulnerable groups. Rev Invest Clin. 2019;71(4):217-25. doi:10.24875/RIC.19002812.
4. Illarionov RA, Kosyakova OV, Vashukova ES, et al. Collection of samples from women at different stages of pregnancy to search for early biomarkers of preterm birth. Cardiovascular Therapy and Prevention. 2020;19(6):2708. (In Russ.) doi:10.15829/1728-8800-2020-2708.
5. Dobrokhotova YuE, Lutsenko NN, Zimina OA. Miscarriage. The role of DNA repair genes. Obstetrics and gynecology. 2015; 9:5- 13. (In Russ.)
6. Pachulia OV, Illarionov RA, Vashukova ES, et al. Quality management of biosampling and data collection from women at different stages of pregnancy for the search for early biomarkers of preterm birth: predicting errors and risk management. Cardiovascular Therapy and Prevention. 2021;20(8):3107. (In Russ.) doi:10.15829/1728-8800-2021-3107.
7. Vashukova ES, Kozyulina PY, Illarionov RA, et al. High-Throughput Sequencing of Circulating MicroRNAs in Plasma and Serum during Pregnancy Progression. Life. 2021;11:1055. doi:10.3390/life11101055.
8. Glotov AS, Kozyulina PYu, Vashukova ES, et al. Pilot study of changes in the level of piRNA in plasma and serum in women at different stages of physiological pregnancy. The Siberian Journal of Clinical and Experimental Medicine. 2021;36(4):62-9. (In Russ.) doi:10.29001/2073-8552-2021-36-4-62-69.
Supplementary files
Review
For citations:
Pachulia O.V., Illarionov R.A., Vashukova E.S., Maltseva A.R., Postnikova T.B., Nasykhova Yu.A., Bespalova O.N., Glotov A.S. Bioresource collection of biosamples from pregnant women at different gestational ages for the search for early biomarkers of pregnancy complications and potential for its use in research. Cardiovascular Therapy and Prevention. 2022;21(11):3399. (In Russ.) https://doi.org/10.15829/1728-8800-2022-3399