Assessment of polygenic risk of hypertension
A. S. Limonova,
A. I. Ershova,
A. V. Kiseleva,
V. E. Ramensky,
Yu. V. Vyatkin,
V. A. Kutsenko,
A. N. Meshkov,
O. M. Drapkina https://doi.org/10.15829/1728-8800-2022-3464
Abstract
Hypertension (HTN) is a leading risk factor for the development of cardiovascular diseases. In recent decades, the rapid development of genetic tests, in particular genome-wide association study (GWAS), has made it possible to identify hundreds of nucleotide sequence variants associated with the development of HTN. One approach to improve the predictive power of genetic testing is to combine information about many nucleotide sequence variants into a single risk assessment system, often referred to as a genetic risk score. Within the framework of this review, the most significant publications on the study of the genetic risk score for HTN will be considered, and the features of their development and application will be discussed.
Supporting agencies: none
About the Authors
A. S. Limonova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Moscow
A. I. Ershova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Moscow
A. V. Kiseleva
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Moscow
V. E. Ramensky
National Medical Research Center for Therapy and Preventive Medicine; Lomonosov Moscow State University
Russian Federation
Russian Federation
Moscow
Yu. V. Vyatkin
National Medical Research Center for Therapy and Preventive Medicine; Novosibirsk National Research State University
Russian Federation
Russian Federation
Moscow, Novosibirsk
V. A. Kutsenko
National Medical Research Center for Therapy and Preventive Medicine; Faculty of Mechanics and Mathematics, Lomonosov Moscow State University
Russian Federation
Russian Federation
Moscow
A. N. Meshkov
National Medical Research Center for Therapy and Preventive Medicine; Pirogov Russian National Research Medical University
Russian Federation
Russian Federation
Moscow
O. M. Drapkina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation
Russian Federation
Moscow
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For citations:
Limonova A.S., Ershova A.I., Kiseleva A.V., Ramensky V.E., Vyatkin Yu.V., Kutsenko V.A., Meshkov A.N., Drapkina O.M. Assessment of polygenic risk of hypertension. Cardiovascular Therapy and Prevention. 2022;21(12):3464. (In Russ.) https://doi.org/10.15829/1728-8800-2022-3464
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