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Association between frailty syndrome and physical activity in patients with coronary artery disease and multivessel coronary artery disease

https://doi.org/10.15829/1728-8800-2023-3620

EDN: KPSIHL

Abstract

AimTo assess the relationship between frailty syndrome (FS) and physical activity (PA) in patients with multivessel coronary artery disease (CAD).

Material and methods. The study included 387 patients with CAD. To identify prefrailty and FS, the authors used the questionnaire “Age is not a drawback”, and the “Mini-­­Cog” screening test. The analysis of PA was carried out using the Global physical activity questionnaire (GPAQ). Statistical processing was carried out using the IBM SPSS Statistics 26.0.0 software. The differences were considered significant at p≤0,050.

Results. The prevalence of FS among CAD patients was 47% (n=181), whereas the prevalence of prefrailty was three times lower — 15% (n=58). The majority of patients with prefrailty and FS (32 (55,2%) and 93 (51,4%), respectively) had low PA levels, while patients with moderate PA levels were not likely to have FS (n=80 (54,1%)). Middle-aged women without FS were significantly more likely to belong to the moderate PA group (p=0,036). The multivariate analysis proved that the PA level is associated with the manifestation of frailty in patients with multivessel CAD.

Conclusion. Manifestation of FS in patients with multivessel CAD is as­sociated with low PA level.

About the Authors

K. E. Krivoshapova
ФГБНУ "Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний"
Russian Federation

Kemerovo



O. L. Barbarash
Research Institute for Complex Issues of Cardiovascular Diseases
Russian Federation

Kemerovo



References

1. Choi J, Ahn A, Kim S, et al. Global Prevalence of Physical Frailty by Fried's Criteria in Community-­­Dwelling Elderly with National Population-­­Based Surveys. J Am Med Dir Assoc. 2015;16(7):548-50. doi:10.1016/j.jamda.2015.02.004.

2. Clegg A, Young J, Iliffe S, et al. Frailty in elderly people. Lancet. 2013;381(9868):752-62. doi:10.1016/S0140-6736(12)62167-9.

3. Roe L, Normand C, Wren MA, et al. The impact of frailty on healthcare utilisation in Ireland: evidence from the Irish longitudinal study on ageing. BMC Geriatr. 2017;17(1):203. doi:10.1186/s12877-017-0579-0.

4. Li G, Ioannidis G, Pickard L, et al. Frailty index of deficit ac­cumulation and falls: data from the Global Longitudinal Study of Osteoporosis in Women (GLOW) Hamilton cohort. BMC Mus­culoskelet Disord. 2014;15:185. doi:10.1186/1471-2474-15-185.

5. Rockwood K, Song X, MacKnight C, et al. A global clinical measure of fitness and frailty in elderly people. CMAJ. 2005;173(5):489-95. doi:10.1503/cmaj.050051.

6. Vegner EA, Krivoshapova KE, Barbarash OL, et al. Challenges in diagnosing frailty syndrome in the elderly population of different countries. Complex Issues of Cardiovascular Diseases. 2020;9(4):95-104. (In Russ.) doi:10.17802/2306-1278-2020-9-4-95-104.

7. Ates Bulut E, Soysal P, Aydin AE, et al. Vitamin B12 deficiency might be related to sarcopenia in older adults. Exp Gerontol. 2017;95:136-40. doi:10.1016/j.exger.2017.05.017.

8. Verlaan S, Aspray TJ, Bauer JM, et al. Nutritional status, body composition, and quality of life in community-­­dwelling sarcopenic and non-sarcopenic older adults: A case-control study. Clin Nutr. 2017;36(1):267-74. doi:10.1016/j.clnu.2015.11.013.

9. Tieland M, Brouwer-­­Brolsma EM, Nienaber-­­Rousseau C, et al. Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people. Eur J Clin Nutr. 2013;67(10):1050-5. doi:10.1038/ejcn.2013.144.

10. Blodgett J, Theou O, Kirkland S, et al. The association between sedentary behaviour, moderate-­­vigorous physical activity and frailty in NHANES cohorts. Maturitas. 2015;80(2):187-91. doi:10.1016/j.maturitas.2014.11.010.

11. Ng TP, Feng L, Nyunt MS, et al. Nutritional, Physical, Cognitive, and Combination Interventions and Frailty Reversal Among Older Adults: A Randomized Controlled Trial. Am J Med. 2015;128(11):1225-36.e1. doi:10.1016/j.amjmed.2015.06.017.

12. Bottle A, Kim D, Hayhoe B, et al. Frailty and comorbidity predict first hospitalisation after heart failure diagnosis in primary care: population-­­based observational study in England. Age. Ageing. 2019;48(3):347-54. doi:10.1093/ageing/afy194.

13. Clark K, Leathers T, Rotich D, et al. Gait Speed Is Not Associated with Vasogenic Shock or Cardiogenic Shock following Cardiac Surgery, but Is Associated with Increased Hospital Length of Stay. Crit Care Res Pract. 2018;23:1538587. doi:10.1155/2018/1538587.

14. Krivoshapova KE, Vegner EA, Terentyeva NA, et al. Frailty syndrome in patients with coronary artery disease. Medical alphabet. 2020;1(19):6-10. (In Russ.) doi:10.33667/2078-5631-2020-19-6-10.

15. Krivoshapova KE, Barbarash OL, Vegner EA, et al. The patient with ischemic heart disease and frailty syndrome: characteristics of multimorbidity and in-hospital prognosis after coronary artery bypass surgery. Russian journal of thoracic and cardiovascular surgery. 2022;64(2):161-8. (In Russ.) doi:10.24022/0236-2791-2022-64-2-161-168.

16. Tkacheva ON, Kotovskaya YV, Runikhina NK, et al. Clinical guidelines on frailty. Russian Journal of Geriatric Medicine. 2020;(1):11-46. (In Russ.) doi:10.37586/2686-8636-1-2020-11-46.

17. Keating XD, Zhou K, Liu X, et al. Reliability and Concurrent Validity of Global Physical Activity Questionnaire (GPAQ): A Systematic Review. Int J Environ Res Public Health. 2019;16(21):4128. doi:10.3390/ijerph16214128.

18. da Silva VD, Tribess S, Meneguci J, et al. Association between frailty and the combination of physical activity level and sedentary behavior in older adults. BMC Public Health. 2019;19(1):709. doi:10.1186/s12889-019-7062-0.

19. Harvey JA, Chastin SF, Skelton DA. Prevalence of sedentary behavior in older adults: a systematic review. Int J Environ Res Public Health. 2013;10(12):6645-61. doi:10.3390/ijerph10126645.

20. Warren TY, Barry V, Hooker SP, et al. Sedentary behaviors increase risk of cardiovascular disease mortality in men. Med Sci Sports Exerc. 2010;42(5):879-85. doi:10.1249/MSS.0b013e3181c3aa7e.

21. Chulkov VS, Gavrilova ES, Chulkov VlS, et al. Primary prevention of cardiovascular disease: focus on improving behavioral risk factors. Russian Journal of Cardiology. 2021;26(S3):4278. (In Russ.) doi:10.15829/1560-4071-2021-4278.

22. Libby P, Ridker PM, Hansson GK; Leducq Transatlantic Network on Atherothrombosis. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol. 2009;54(23):2129-38. doi:10.1016/j.jacc.2009.09.009.

23. Junius-­­Walker U, Onder G, Soleymani D, et al.; ADVANTAGE JA WP4 Group. The essence of frailty: a systematic review and qualitative synthesis on frailty concepts and definitions. Eur J Intern Med. 2018;56:3-10. doi:10.1016/j.ejim.2018.04.023.

24. Colbert LH, Visser M, Simonsick EM, et al. Physical activity, exercise, and inflammatory markers in older adults: findings from the Health, Aging and Body Composition Study. J Am Geriatr Soc. 2004;52(7):1098-104. doi:10.1111/j.1532-5415.2004.52307.x.

25. Tarazona-­­Santabalbina FJ, Gómez-­­Cabrera MC, Pérez-­­Ros P, et al. A Multicomponent Exercise Intervention that Reverses Frailty and Improves Cognition, Emotion, and Social Networking in the Community-­­Dwelling Frail Elderly: A Randomized Clinical Trial. J Am Med Dir Assoc. 2016;17(5):426-33. doi:10.1016/j.jamda.2016.01.019.

26. Tolga S. Coronary heart disease and exercise. Turk J Sports Med. 2016;51(2):056-068. doi:10.5152/tjsm.2016.007.

27. Pelliccia A, Sharma S, Gati S, et al. 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Russian Journal of Cardiology. 2021;26(5):4488. (In Russ.) doi:10.15829/1560-4071-2021-4488.


Supplementary files

What is already known about the subject?

  • Frailty syndrome is an important predictor of va­rious adverse outcomes, including disability, ho­spitalization, premature death and low resi­stance to stress.

What might this study add?

  • The prevalence of prefrailty and frailty is high among elderly, senile, and even middle-aged pa­tients with multivessel coronary artery disease.
  • Manifestation of frailty syndrome in patients with multivessel coronary artery disease is associated with low level of physical activity.

Review

For citations:


Krivoshapova K.E., Barbarash O.L. Association between frailty syndrome and physical activity in patients with coronary artery disease and multivessel coronary artery disease. Cardiovascular Therapy and Prevention. 2023;22(8):3620. (In Russ.) https://doi.org/10.15829/1728-8800-2023-3620. EDN: KPSIHL

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ISSN 1728-8800 (Print)
ISSN 2619-0125 (Online)