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Importance of biological markers in the assessment of endothelial dysfunction

https://doi.org/10.15829/1728-8800-2024-4061

EDN: XIZKXF

Abstract

Endothelial dysfunction (ED) is a pathogenetic link in many cardio­vas­cular diseases. One of the promising approaches to non-invasi­ve diagnostics and assessment of the ED severity may be the deter­mi­nation of specific blood biomarkers. This review is devoted to the patho­genetic role of some biochemical and molecular factors associated with ED, as potential biomarkers of noncommunicable diseases.

About the Authors

Yu. S. Timofeev
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


M. A. Mikhailova
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


O. N. Dzhioeva
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


O. M. Drapkina
National Medical Research Center for Therapy and Preventive Medicine
Russian Federation

Moscow


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Supplementary files

What is already known about the subject?

  • Endothelial dysfunction (ED) is a primary link in the pathogenesis of cardiovascular diseases.
  • Endothelium pathological changes are characterized by impaired production and alterations in the composition and concentration of produced bioactive compounds.
  • Currently, a fairly narrow range of laboratory parameters is used to assess ED, while the significance of many of them remains insufficiently studied.

What might this study add?

  • A systematization of literary data devoted to the study of ED biochemical markers was carried out, starting with generally accepted ones, such as nitric oxide metabolites and endothelin 1-21, and ending with less studied biochemical and molecular markers.
  • ED-associated parameters are described, including endoglin, endocan, syndecan family proteins and micro-RNA, which can be considered as potential biomarkers of cardiovascular disease risk.

Review

For citations:

Timofeev Yu.S., Mikhailova M.A., Dzhioeva O.N., Drapkina O.M. Importance of biological markers in the assessment of endothelial dysfunction. Cardiovascular Therapy and Prevention. 2024;23(9):4061. (In Russ.) https://doi.org/10.15829/1728-8800-2024-4061. EDN: XIZKXF

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